2-Hydroxyethyltrimethylammonium (R)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alaninate | 10030-88-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Hydroxyethyltrimethylammonium (R)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alaninate
• 英文别名: 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate;2-hydroxyethyl(trimethyl)azanium
• CAS: 10030-88-3
• 化学式: C14H30N2O6
• 分子量: 322.4
• InChiKey: HXCGBBALZREMAS-FJXQXJEOSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.69
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Granular agent for ruminant and production method thereof
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP0276781A2

  公开（公告）日：1988-08-03

  A granular agent for a ruminant comprising a solid substance containing at least one physiologically active substance coated with a thin film of a waxy substance having a melting point of 40°C to 120°C, the thin film having a thickness of 0.2 to 20 µm and containing therein fine solid particles having a melting point of 120°C or more and an average particle size of 10 µm or less and the fine solid particles being substantially slightly soluble in water and insoluble in the waxy substance under a neutral condition.

  一种用于反刍动物的颗粒剂，包括一种固体物质，其中含有至少一种生理活性物质，表面涂有一层熔点为 40°C 至 120°C 的蜡质物质薄膜，薄膜厚度为 0.2 至 20 微米，其中含有细小固体颗粒，熔点为 120°C 或以上，平均粒径为 10 微米或以下，细小固体颗粒在中性条件下基本上微溶于水，不溶于蜡质物质。
• Feed additives for ruminants
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0467401A1

  公开（公告）日：1992-01-22

  A feed additive granule for ruminants comprising a granulated physiologically active substance as the core, a first coating layer placed on the surface of said core, said first coating layer containing a high molecular substance which dissolves or swells in water in an acidic pH region of not greater than 5.5 and is stable in a pH region of 5.6 to 8.0, and a second coating layer placed on said first coating layer, said second coating layer being of a substance which is stable in an acidic pH region of not greater than 5.5, dissolves or swells in water in a pH region of 5.6 to 8.0 and is acceptable to ruminants, and some modifications thereof, as well as feed for ruminants comprising such a novel feed additive.

  一种用于反刍动物的饲料添加剂颗粒，包括作为核心的粒状生理活性物质、置于所述核心表面的第一包衣层，所述第一包衣层含有一种高分子物质，该物质在酸性pH值不大于5.5的区域内溶解或溶胀于水，并在pH值为5.6至8.0的区域内稳定。0 的酸性 pH 值区域内稳定、在 5.6 至 8.0 的 pH 值区域内溶解或溶胀且反刍动物可接受的物质，以及其一些改性，以及包含这种新型饲料添加剂的反刍动物饲料。
• Feed additive composition for ruminants
  申请人：Ajinomoto Co., Inc.

  公开号：EP0588346A2

  公开（公告）日：1994-03-23

  A feed additive composition containing a biologically active substance which is stable in the rumen of ruminants while allowing its efficient digestion and absorption in the abomasum and its subsequent digestive tract is provided. The feed additive composition for ruminants according to this invention is characterized in that a core which contains a biologically active substance is coated with a coating composition which contains at least a) and b) below. a) at least one substance selected from the group consisting of linear or branched saturated or unsaturated aliphatic monocarboxylic acids of 12-22 carbon atoms or salts thereof, hardened vegetable fats and oils, hardened animal fats and oils and wax; and b) a substance indicated in i) and/or ii) below. i) one or more linear or branched saturated or unsaturated aliphatic monocarboxylic acids or 11 carbon atoms or less, and ii) one or more substances selected from the group consisting of nucleic acids, nucleotides, nucleosides, bases composing nucleic acids and salts thereof.

  本发明提供了一种含有生物活性物质的饲料添加剂组合物，该生物活性物质在反刍动物的瘤胃中稳定，同时允许其在腹腔和随后的消化道中有效消化和吸收。 根据本发明的反刍动物饲料添加剂组合物，其特征在于含有生物活性物质的核心部分涂有涂层组合物，该涂层组合物至少包含以下a)和b)。 a) 至少一种物质，选自 12-22 碳原子的直链或支链饱和或不饱和脂肪族单羧酸或其盐、硬化植物油脂、硬化动物油脂和蜡组成的组；以及 b) 下文 i) 和/或 ii) 所述物质。 i) 一种或多种线性或支链饱和或不饱和脂肪族单羧酸，或 11 个碳原子或更少，和 ii) 一种或多种选自核酸、核苷酸、核苷、核酸碱及其盐类的物质。
• An additive composition for ruminant feed
  申请人：Ajinomoto Co., Inc.

  公开号：EP0678246A1

  公开（公告）日：1995-10-25

  A granular additive composition for ruminant feed which stably protects the biologically active substance in the rumen of the ruminant and allows it to be effectively digested and absorbed in the digestive organs after the abomasum is provided with consideration of safety and economy. This granular additive composition for ruminant feed comprises a core comprising a biologically active substance and a coating composition coated thereon, said coating composition comprising 90 to 68 % by weight of (A) at least one hydrophobic protecting substance selected from the group consisting of hardened animal and plant oil and fat, an animal and plant fat, and a fatty acid ester, 2 to 10 % by weight of (B) a surface active agent compatible with said hydrophobic protecting substance (A), and 8 to 30 % by weight of (C) talc powder. The granular additive composition simultaneously has excellent protecting property in the rumen of the ruminant and extremely excellent releasability in the digestive organs after the abomasum.

  考虑到安全性和经济性，提供了一种反刍动物饲料颗粒添加剂组合物，它能在反刍动物的瘤胃中稳定地保护生物活性物质，并使其在瘤胃后的消化器官中被有效消化和吸收。 这种用于反刍动物饲料的颗粒状添加剂组合物包括由生物活性物质组成的核心和涂覆在其上的包衣组合物，所述包衣组合物包括 90% 至 68% （重量百分比）的（A）至少一种疏水保护物质，该物质选自由硬化的动植物油脂、动植物脂肪和脂肪酸酯组成的组、 以重量计，2%至 10%的(B)与所述疏水保护物质(A)相容的表面活性剂，以及 8-30 %（重量百分比）的（C）滑石粉。 这种颗粒状添加剂组合物在反刍动物的瘤胃中同时具有极佳的保护性能，在腹腔后的消化器官中具有极佳的释放性。
• Method of growing bacteria to deliver bioactive compounds to the intestine of ruminants
  申请人：Sage Biosciences Inc.

  公开号：EP2311937A1

  公开（公告）日：2011-04-20

  Methods for increasing the resistance to rumen inactivation of a cultured Gram positive bacteria strain useful for gastrointestinal delivery of bioactive compounds to ruminants, which includes the steps of growing a culture of the bacteria strain through at least one passage in a growth medium containing an amount of lysozyme effective to induce the growth of bacterial cell walls resistant to protozoal predation; and recovering the bacteria strain from the lysozyme-containing medium. Rumen-bypass feed supplements produced by the inventive method are also disclosed, as well as methods for supplementing the diet of a ruminant with the rumen bypass feed supplements and an in vitro method for evaluating the resistance of Gram positive bacteria strains to rumen inactivation in vivo.

  提高用于向反刍动物胃肠道输送生物活性化合物的培养革兰氏阳性菌菌株的抗瘤胃灭活能力的方法，包括以下步骤：在含有一定量溶菌酶的生长培养基中培养至少一个菌株，该培养基能有效诱导抗原生动物捕食的细菌细胞壁生长；以及从含溶菌酶的培养基中回收菌株。本发明还公开了用本发明方法生产的瘤胃旁路饲料补充剂，以及用瘤胃旁路饲料补充剂补充反刍动物饮食的方法和评估革兰氏阳性菌菌株对体内瘤胃灭活的抗性的体外方法。