2,3-dihydroxypropyl dihydrogen phosphate;(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | 146-39-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: 2,3-dihydroxypropyl dihydrogen phosphate;(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• CAS: 146-39-4
• 化学式: C23H33N2O8P
• 分子量: 496.5
• InChiKey: ZCLWGJJWKJYQIM-DSXUQNDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.62
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  153
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Compositions and methods for treating skin conditions
  申请人：AkPharma, Inc.

  公开号：US20040037766A1

  公开（公告）日：2004-02-26

  A skin treatment composition containing ionic calcium and a dermatologically acceptable water-soluble, water-miscible or water-based carrier is provided for treating a skin condition in a mammal, such as dry skin, dry scalp, a burn, sunburn, irritation or minor wound. The ionic calcium is preferably present as the water soluble calcium glycerophosphate salt. The composition may be present in a formulation such as bar soap, liquid soap, bath, lotion, cream, gel, or ointment, and may also be useful for stimulating more youthful skin cells and for improving the appearance of the skin. Methods for treating skin conditions and for accelerating cellular repair include topically applying to the skin an effective amount of ionic calcium, preferably as calcium glycerophosphate, and an &agr;-hydroxy acid such as lactic acid.

  提供了一种含有离子钙和皮肤病学上可接受的水溶性、水溶性或水基载体的皮肤治疗组合物，用于治疗哺乳动物的皮肤状况，如皮肤干燥、头皮干燥、烧伤、晒伤、刺激或轻微伤口。离子钙最好以水溶性甘油磷酸钙盐的形式存在。该组合物可以存在于肥皂、皂液、浴液、乳液、膏霜、凝胶或软膏等配方中，也可用于刺激更年轻的皮肤细胞和改善皮肤外观。治疗皮肤状况和加速细胞修复的方法包括在皮肤局部施用有效量的离子钙（最好是甘油磷酸钙）和&agr;-羟基酸（如乳酸）。
• COMPOSITION FOR TREATMENT OF MALIGNANT TUMORS AND THEIR METASTASES
  申请人：Co Enzyme Technology Ltd.

  公开号：EP0797453B1

  公开（公告）日：2003-03-26
• COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS
  申请人：AKPHARMA INC.

  公开号：EP1539105A2

  公开（公告）日：2005-06-15
• METHODS FOR IMPROVING HEALING OF AN ORAL LESION USING A GLYCEROPHOSPHATE SALT
  申请人：Prelief Inc.

  公开号：EP2180895A1

  公开（公告）日：2010-05-05
• METHODS FOR TREATING OR PREVENTING HEMORRHAGIC CYSTITIS USING A GLYCEROPHOSPHATE SALT
  申请人：Kligerman Alan E.

  公开号：US20100029590A1

  公开（公告）日：2010-02-04

  Glycerophosphate salts have been found to mitigate the syndromes or conditions of discomfort associated with hem-orrhagic cystitis. Therefore, methods are provided for treating or preventing the syndromes or conditions of discomfort associated with hemorrhagic cystitis using a glycerophosphate salt, hi particular, methods are provided for treating or preventing the syndromes or conditions of discomfort associated with hemorrhagic cystitis using calcium glycerophosphate (CGP).