5-amino-4-(1H-benzimidazol-2-yl)-1-(3,5-dimethoxyphenyl)-2H-pyrrol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 5-amino-4-(1H-benzimidazol-2-yl)-1-(3,5-dimethoxyphenyl)-2H-pyrrol-3-one
• 化学式: C₁₉H₁₈N₄O₃
• 分子量: 350.4
• InChiKey: JRRMDNVTWNUJAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  93.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• MODULATORS OF OPIOID RECEPTORS AND METHODS OF USE THEREOF
  申请人：Sunovion Pharmaceuticats Inc.

  公开号：US20140288050A1

  公开（公告）日：2014-09-25

  Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
• US9580409B2
  申请人：——

  公开号：US9580409B2

  公开（公告）日：2017-02-28
• [EN] MODULATORS OF OPIOID RECEPTORS AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DE RÉCEPTEURS DES OPIOÏDES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SUNOVION PHARMACEUTICALS INC

  公开号：WO2013070659A1

  公开（公告）日：2013-05-16

  Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.