[2-(吗啉-4-羰基)苯基]-吗啉-4-基-甲酮 | 6425-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: [2-(吗啉-4-羰基)苯基]-吗啉-4-基-甲酮
• 英文名称: 4,4'-phthaloyl-bis-morpholine
• 英文别名: Phthalsaeure-dimorpholid；Benzene-1,2-diylbis(morpholin-4-ylmethanone)；[2-(morpholine-4-carbonyl)phenyl]-morpholin-4-ylmethanone
• CAS: 6425-65-6
• 化学式: C₁₆H₂₀N₂O₄
• 分子量: 304.346
• InChiKey: ALUQMBZPJUOGAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 邻苯二甲酰氯 生成 [2-(吗啉-4-羰基)苯基]-吗啉-4-基-甲酮
  参考文献：
  名称：

  Kerfanto,M., Bulletin de la Societe Chimique de France, 1965, p. 3537 - 3544

  摘要：

  DOI：

文献信息

• The aminocarbonylation of 1,2-diiodoarenes with primary and secondary amines catalyzed by palladium complexes with imidazole ligands
  作者：Przemysław Wójcik、Anna M. Trzeciak

  DOI：10.1016/j.apcata.2018.04.043

  日期：2018.6

  The efficient carbonylative cyclization of 1,2-diiodobenzene with different primary and secondary amines was performed using a palladium complex with an imidazole ligand, PdCl2(BIM)2, as a catalyst. In reactions performed at 1 atm of CO with primary amines, phthalimides were obtained as the only products with yields of up to 100% in 4 h. An even shorter time, 1 h, was sufficient to obtain the same

  使用具有咪唑配体PdCl 2（BIM）2的钯配合物作为催化剂，用不同的伯胺和仲胺对1,2-二碘苯进行有效的羰基环化反应。在1大气压的CO与伯胺进行的反应中，邻苯二甲酰亚胺是唯一的产物，在4小时内收率高达100％。甚至更短的1小时时间也足以获得使用2-碘代苯甲酸甲酯代替1,2-二碘代苯作为底物的相同产品。在与仲胺的类似反应中，1,2-二碘苯被转化为三种产物，其形成量取决于反应条件。Pd NP和可溶性钯中间体的存在表明它们参与了催化反应。
• Decolorizable ink composition and ink jet printer using the ink composition
  申请人：Ricoh Company, Ltd.

  公开号：EP1149877A1

  公开（公告）日：2001-10-31

  In an ink composition, a coloring agent, a color developer, and a decolorization agent are dissolved or dispersed in a solvent. The ink is capable of being colored at 40°C or less, with the coloring agent reacting with the color developer to form a bonded structure, and also capable of being decolorized when heated to 100°C or more, with the bonded structure being ruptured to liberate the color developer therefrom, and the liberated color developer being chemically bonded to the decolorization agent. An ink jet printer is provided with a paper feeder for feeding a recording sheet for ink jet printing, a recorder for recording an ink image on the recording sheet fed from the paper feeder using the above-mentioned ink composition, and a paper discharger for discharging the recording sheet from the ink jet printer. By further providing an eraser, the ink image recorded on the recording sheet by the recorder can be erased, thereby achieving recycling of the recording sheet.

  在一种油墨组合物中，着色剂、显色剂和脱色剂溶解或分散在溶剂中。这种墨水能在 40°C 或更低温度下着色，着色剂与显色剂反应形成粘合结构，也能在加热到 100°C 或更高温度时脱色，粘合结构破裂，显色剂从中释放出来，释放出来的显色剂与脱色剂化学粘合。喷墨打印机具有送纸器，用于送入用于喷墨打印的记录纸；记录器，用于使用上述墨水成分在从送纸器送入的记录纸上记录墨水图像；以及排纸器，用于将记录纸从喷墨打印机中排出。通过进一步提供一个擦除器，记录器记录在记录纸上的墨水图像可以被擦除，从而实现记录纸的循环利用。
• Highly Efficient Aminocarbonylation of Iodoarenes at Atmospheric Pressure Catalyzed by a Robust Acenaphthoimidazolyidene Allylic Palladium Complex
  作者：Weiwei Fang、Qinyue Deng、Mizhi Xu、Tao Tu

  DOI：10.1021/ol401550h

  日期：2013.7.19

  A robust allylic palladium-NHC complex was developed and exhibited extremely high catalytic activity toward aminocarbonylation of various (hetero)aryl iodides under atmospheric carbon monoxide pressure, in which a broad range of secondary and primary amines were well tolerated. In addition, the concise synthesis of an anticancer drug tamibarotene was accomplished even in a gram scale, further highlighting the practical applicability of the protocol.
• US6527384B2
  申请人：——

  公开号：US6527384B2

  公开（公告）日：2003-03-04