[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-12-butanoyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-25-yl] 3-methylbutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-12-butanoyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-25-yl] 3-methylbutanoate
• 化学式: C₄₆H₇₀O₁₇
• 分子量: 895.0
• InChiKey: OUVYQBNLDHLZNW-ZMHJAGKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  63
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  240
• 氢给体数：
  4
• 氢受体数：
  17

文献信息

• Immunomodulating bryostatins
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0324574A2

  公开（公告）日：1989-07-19

  Low concentrations of the protein kinase C activators, bryostatins 1 and 2 synergized with rBSF-1 are useful in triggering differentiation (granule enzyme expression) and CTL development in naive, resting lymph node T-cells. Bryostatin greatly enhances efficiency of rIL-2 in triggering development of in vivo primed CTL during in vitro incubation, thereby providing evidence for the use of lower concentrations of rIL-2 for in vivo tumor rejection. Both bryostatin 1 and 2, trigger cytotoxicity of CTL clones against Ag-non-bearing target cells and inhibit CTL cytotoxicity against Ag-specific target cells. Bryostatin 1 and 2 synergize with Ca⁺⁺ ionophores in triggering the exocytosis of cytolytic granules from CTL at very low concentrations. Because of the lack of tumor promoting activity in the bryostatins, they are useful per se as immunomodulating drugs and as potentiators for rIL-2 in adoptive immunotherapy.

  低浓度的蛋白激酶 C 激活剂白屈菜素 1 和白屈菜素 2 与 rBSF-1 协同作用，有助于触发天真、静止淋巴结 T 细胞的分化（颗粒酶表达）和 CTL 发育。在体外培养过程中，布赖司他汀可大大提高 rIL-2 触发体内引诱 CTL 发育的效率，从而为使用较低浓度的 rIL-2 进行体内肿瘤排斥提供了证据。白僵菌素 1 和 2 都能激发 CTL 克隆对不含蚕豆的靶细胞的细胞毒性，并抑制 CTL 对蚕豆特异性靶细胞的细胞毒性。在极低浓度下，Bryostatin 1 和 2 与 Ca⁺⁺ 离子通道协同触发 CTL 细胞溶解颗粒的外排。由于白藜芦醇不具有肿瘤促进活性，因此它们本身可作为免疫调节药物，也可作为采用性免疫疗法中 rIL-2 的增效剂。
• Neristatin 1 and a composition comprising the compound for the treatment of lymphocytic leukemia
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0530980A1

  公开（公告）日：1993-03-10

  The marine bryozoan Bugula neritina has been found to contain a novel 22-membered macrocyclic lactone of formula (I) which is an inhibitor of lymphocytic leukemia as measured by the US National Cancer Institute's P 388 and in vitro evaluation system. The novel lactone is herein denominated "neristatin 1" and is elucidated.

  研究发现，海洋贝类 Bugula neritina 中含有一种新的 22 元大环内酯，其化学式为式（I），根据美国国家癌症研究所的 P 388 和体外评估系统测定，该内酯是一种淋巴细胞白血病抑制剂。 本文将这种新型内酯命名为 "neristatin 1"，并对其进行了阐明。
• Bryostatins
  申请人：ARIZONA BOARD OF REGENTS, ARIZONA STATE UNIVERSITY

  公开号：EP0178048B1

  公开（公告）日：1994-10-12
• METHODS AND COMPOSITIONS FOR TREATMENT OF RETT SYNDROME
  申请人：Neurotrope Bioscience, Inc.

  公开号：EP3452482A1

  公开（公告）日：2019-03-13
• US4611066A
  申请人：——

  公开号：US4611066A

  公开（公告）日：1986-09-09