1,2-Bis-methylamino-4-nitrobenzol | 1457-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-Bis-methylamino-4-nitrobenzol
• 英文别名: N~1~,N~2~-Dimethyl-4-nitrobenzene-1,2-diamine；1-N,2-N-dimethyl-4-nitrobenzene-1,2-diamine
• CAS: 1457-55-2
• 化学式: C₈H₁₁N₃O₂
• 分子量: 181.194
• InChiKey: QBFWFMYZBYUMHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-Bis-methylamino-4-nitrobenzol 、 乙酸酐 生成 N-Acetyl-N,N'-dimethyl-4(5)-nitro-o-phenylendiamin
  参考文献：
  名称：

  Porai-Koschiz; Murawitsch, Zhurnal Obshchei Khimii, 1956, vol. 26, p. 2487,2391; engl. Ausg. S. 2779, 2782

  摘要：

  DOI：

文献信息

• Novel Therapeutic Agents
  申请人：Purdue Pharmaceutical Products L.P.

  公开号：US20150086551A1

  公开（公告）日：2015-03-26

  The present invention relates to a class of hydroxamic acid compounds of Formula (I), which act as alkylating agents and/or inhibitors of the HDAC pathway, having potential utility in the treatment of a neoplastic disease and immune diseases.
• [EN] SYNTHESIS OF AND CURING ADDITIVES FOR PHTHALONITRILES<br/>[FR] SYNTHÈSE D'ADDITIFS DE DURCISSEMENT DE PHTHALONITRILES
  申请人：US GOVERNMENT

  公开号：WO2015183518A1

  公开（公告）日：2015-12-03

  A method of: providing a solution of a dichloroaromatic compound having an electron- withdrawing group bound to each aromatic ring containing one of the chloride groups; a dihydroxyaromatic compound or anion thereof; an organic transition metal complex or a transition metal salt; a base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form a dimetallic salt of an aromatic ether oligomer. The molar ratio of the dihydroxyaromatic compound to the dichloroaromatic compound is greater than 2: 1. Water formed during the heating is concurrently distilled from the solution. A composition having a mixture of the below compounds having a mole ratio of at least 1:20. Ar1 and Ar2 are independently selected aromatic groups. A composition comprising phthalonitrile compounds that comprise at least 5 mol% of the first compound below.