2-methylprop-2-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methylprop-2-enoic acid
• 化学式: C8H12O4
• 分子量: 172.18
• InChiKey: RWHRFHQRVDUPIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SILANE COUPLING COMPOUNDS AND MEDICAL AND/OR DENTAL CURABLE COMPOSITIONS COMPRISING THE SAME
  申请人：KABUSHIKI KAISHA SHOFU

  公开号：US20190300552A1

  公开（公告）日：2019-10-03

  The present invention relate to a novel silane coupling agent and a medical and/or dental curable composition comprising the same. It is an object of the present invention to provide a novel silane coupling agent that imparts high affinity to a radical polymerizable monomer, thereby imparting high mechanical strength, flexibility and durability when used for a medical and/or dental curable composition, and an inorganic filler surface-treated with the novel silane coupling agent and a novel medical and/or dental curable composition. A silane coupling agent including repeating units such as a urethane bond and polyethylene glycol (ether bond) at a specific position is used.

  本发明涉及一种新型硅烷偶联剂以及包括该偶联剂的医用和/或牙科可固化组合物。本发明的目的是提供一种新型硅烷偶联剂，使其对自由基聚合单体具有高亲和力，从而在用于医用和/或牙科可固化组合物时赋予高机械强度、柔韧性和耐久性，并且包括经新型硅烷偶联剂表面处理的无机填料和新型医用和/或牙科可固化组合物。该硅烷偶联剂包括在特定位置具有尿素键和聚乙二醇（醚键）等重复单元。
• [EN] A DENTAL COMPOSITION<br/>[FR] COMPOSITION DENTAIRE
  申请人：STICK TECH OY

  公开号：WO2020035321A1

  公开（公告）日：2020-02-20

  A dental composition comprising10-50 wt-% of a methacrylate-based first matrix component, a polymerisation system and as a second matrix component 1-50 wt-% of a compound having a general formula (I).

  一种牙科组合物，包括10-50重量％的甲基丙烯酸酯基第一基体组分，一个聚合体系，以及作为第二基体组分的具有一般式(I)的化合物，其含量为1-50重量％。
• ENZYMATICALLY AND HYDROLYTICALLY STABLE RESINS, RESIN MONOMERS, AND RESIN COMPOSITES FOR USE IN DENTAL PREVENTIVE AND RESTORATIVE APPLICATIONS
  申请人：ADA Foundation

  公开号：US20150257986A1

  公开（公告）日：2015-09-17

  A composition of matter includes one or more functionalized vinylbenzyl components of the formula covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH 2 —CH 2 —O—) moieties and/or derivatives thereof, and one or more benzene (C 6 H 6 ) and/or derivatives thereof; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

  一种物质的组成包括一个或多个功能化的乙烯苯基组分，其化学式为与一个或多个R功能组分共价连接；所述一个或多个R功能基从包括一个或多个羟甲基（—CHOH—）基团及/或其衍生物、一个或多个乙氧基（—CH2— —O—）基团及/或其衍生物、一个或多个苯基（C6H6）及/或其衍生物的群组中选择；以及连接功能化的乙烯苯基组分和R功能组分的醚键。
• ASYMMETRIC BIFUNCTIONAL SILYL MONOMERS AND PARTICLES THEREOF AS PRODRUGS AND DELIVERY VEHICLES FOR PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL AGENTS
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20170021030A1

  公开（公告）日：2017-01-26

  Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.

  描述了包含共价连接的药物、化学和生物试剂的不对称双功能硅基（ABS）单体。这些试剂也可以通过硅基团共价结合到传递载体上，以将试剂传递到所需的靶标或区域。还描述了包含共价连接试剂的ABS单体的传递载体，以及与ABS单体共价连接的载体。本文描述的硅基修饰可以修改试剂和载体的性质，从而提供所需的溶解性、稳定性、疏水性和靶向性。
• [EN] RANDOM COPOLYMER THERAPEUTIC AGENT CARRIERS AND ASSEMBLIES THEREOF<br/>[FR] SUPPORTS POUR AGENTS THÉRAPEUTIQUES À BASE D'UN COPOLYMÈRE ALÉATOIRE ET ENSEMBLES À BASE DE CEUX-CI
  申请人：UNIV WASHINGTON CT COMMERCIALI

  公开号：WO2015073579A1

  公开（公告）日：2015-05-21

  Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.

  本文提供的是包括包围核心的壳体的粒子组装体。壳体包括一种粒子稳定的随机共聚物。核心包括一种核心随机共聚物。这些粒子组装体具有仿生设计，其中包含离散化学和生物功能的聚合物组分被设计成自发自组装成粒子。本文还提供了具有共轭治疗剂的随机共聚物，这些治疗剂可以被酶或水从共聚物中裂解。