3-(2-Oxoazepan-1-yl)propanamide | 88948-37-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2-Oxoazepan-1-yl)propanamide
• CAS: 88948-37-2
• 化学式: C₉H₁₆N₂O₂
• 分子量: 184.24
• InChiKey: CERAKXNNJWFTNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrrole substituted 2-indolinone protein kinase inhibitors
  申请人：Tang Peng Cho

  公开号：US20050176802A1

  公开（公告）日：2005-08-11

  The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及吡咯取代的2-吲哚酮化合物及其药学上可接受的盐，这些化合物调节蛋白激酶的活性，因此预计可用于预防和治疗蛋白激酶相关的细胞疾病，如癌症。
• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• AGENT FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS
  申请人：Kyoto University

  公开号：EP3246046A1

  公开（公告）日：2017-11-22

  The present invention provides a prophylactic and/or therapeutic agent for amyotrophic lateral sclerosis (ALS), which contains one or more kinase inhibitors selected from the group consisting of an epithelial cell growth factor receptor (EGFR) inhibitor, a fibroblast growth factor receptor (FGFR) inhibitor, an Aurorakinase inhibitor, a protein kinase A (PKA) inhibitor, a protein kinase C (PKC) inhibitor, an MEK inhibitor, an Met inhibitor, a JNK inhibitor, a Syk inhibitor and a JAK inhibitor, a prostaglandin analogue and an estrogen receptor antagonist, or one or more kinase inhibitors selected from the group consisting of Tivozanib and an analog thereof, SB 216763, Cdk2 Inhibitor II, BUDESONIDE, RIBOFLAVIN, alpha-TOCHOPHEROL, AMODIAQUINE, SU9516, Sunitinib and an analog thereof, GSK-3 Inhibitor XIII, Bisindolylmaleimide I, HYDROQUINONE, FLUNISOLIDE, MGCD-265, Indirubin-3'-monoxime, HYDRASTINE (1R,9S), PIPERINE, BUTAMBEN, Axitinib and an analog thereof, APOMORPHINE, FENBUFEN, Bosutinib (SKI-606) and an analog thereof, a Wee1 Inhibitor, Cdk2 Inhibitor IV, NU6140, 3-hydroxybutyric acid, AT9283, Imatinib, Nilotinib, Rebastinib, and Bafetinib for the prophylaxis and/or treatment of ALS. Particularly, using a compound already on the market as a pharmaceutical product, a pharmaceutical product for the prophylaxis or treatment of ALS can be developed rapidly at a low cost.

  本发明提供了一种肌萎缩性脊髓侧索硬化症（ALS）的预防和/或治疗剂，它含有一种或多种激酶抑制剂，这些激酶抑制剂选自由上皮细胞生长因子受体（EGFR）抑制剂、成纤维细胞生长因子受体（FGFR）抑制剂、Aurorakinase抑制剂、蛋白激酶A（PKA）抑制剂、蛋白激酶C（PKC）抑制剂组成的组、成纤维细胞生长因子受体 (FGFR) 抑制剂、Aurorakinase 抑制剂、蛋白激酶 A (PKA) 抑制剂、蛋白激酶 C (PKC) 抑制剂、MEK 抑制剂、Met 抑制剂、JNK 抑制剂、Syk 抑制剂和 JAK 抑制剂、前列腺素类似物和雌激素受体拮抗剂、或一种或多种激酶抑制剂，这些激酶抑制剂选自以下组别：Tivozanib 及其类似物、SB 216763、Cdk2 抑制剂 II、BUDESONIDE、RIBOFLAVIN、alpha-TOCHOPHEROL、AMODIAQUINE、SU9516、Sunitinib 及其类似物、GSK-3 抑制剂 XIII、Bisindolylmaleimide I、HYDROQUINONE、FLUNISOLIDE、MGCD-265、吲哚啉-3'-monoxime、氢化胱氨酸 (1R,9S)、哌啶、布坦本、阿希替尼及其类似物、阿朴磷、芬布芬、博苏替尼 (SKI-606) 及其类似物、Wee1抑制剂、Cdk2抑制剂IV、NU6140、3-羟基丁酸、AT9283、伊马替尼、尼洛替尼、雷巴替尼和巴非替尼，用于预防和/或治疗ALS。特别是，利用已作为药品上市的化合物，可以低成本快速开发出预防或治疗 ALS 的药品。
• BOSUTINIB, SUNITINIB, TIVOZANIB, IMATINIB, NILOTINIB, REBASTINIB OR BAFETINIB FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS
  申请人：KYOTO UNIVERSITY

  公开号：EP3789027A1

  公开（公告）日：2021-03-10

  The present invention provides a compound for use in the prophylaxis and/or treatment of amyotrophic lateral sclerosis (ALS), wherein said compound is selected from the group consisting of bosutinib, sunitinib, tivozanib, imatinib, nilotinib, rebastinib and bafetinib. Particularly, using a compound already on the market as a pharmaceutical product, a pharmaceutical product for the prophylaxis or treatment of ALS can be developed rapidly at a low cost.

  本发明提供了一种用于预防和/或治疗肌萎缩性脊髓侧索硬化症（ALS）的化合物，其中所述化合物选自由博苏替尼、舒尼替尼、替沃扎尼、伊马替尼、尼洛替尼、瑞帕替尼和巴非替尼组成的组。特别是，利用已作为药品上市的化合物，可以低成本快速开发预防或治疗 ALS 的药品。
• PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS
  申请人：Sugen, Inc.

  公开号：EP1255752B1

  公开（公告）日：2007-08-08