5,5’,6,6’-tetrafluoro-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid | 156638-52-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5,5’,6,6’-tetrafluoro-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid
• 英文别名: 1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid；TF-Bapta；2-[2-[2-[6-[bis(carboxymethyl)amino]-2,3-difluorophenoxy]ethoxy]-N-(carboxymethyl)-3,4-difluoroanilino]acetic acid
• CAS: 156638-52-7
• 化学式: C₂₂H₂₀F₄N₂O₁₀
• 分子量: 548.402
• InChiKey: VPFWHRZSAIFDBO-UHFFFAOYSA-N

物化性质

• 沸点：
  799.5±60.0 °C(Predicted)
• 密度：
  1.633±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  174
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• Non-invasive sensing of free metal ions using ion chemical exchange saturation transfer
  申请人：The Johns Hopkins University

  公开号：US10753892B2

  公开（公告）日：2020-08-25

  The invention features a novel non-invasive approach for imaging, detecting and/or sensing metal ions with improved sensitivity and specificity in a biological sample or tissue. In certain embodiments, the invention provides a MR contrast-based approach for imaging, detecting and/or sensing metal ions in the biological sample/tissue containing various background ions by using 19F-based chemical exchange saturation transfer (CEST) technique.

  本发明采用一种新颖的非侵入性方法，以更高的灵敏度和特异性对生物样本或组织中的金属离子进行成像、检测和/或传感。在某些实施方案中，本发明提供了一种基于磁共振对比的方法，通过使用基于 19F 的化学交换饱和转移（CEST）技术，对含有各种背景离子的生物样本/组织中的金属离子进行成像、检测和/或传感。
• Compositions and methods for detection and isolation of phosphorylated molecules
  申请人：——

  公开号：US20040038306A1

  公开（公告）日：2004-02-26

  The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.

  本发明涉及磷酸盐结合化合物，可用于结合、检测和分离磷酸化目标分子，包括随后鉴定与磷酸化目标分子或能够被磷酸化的分子相互作用的目标分子。本发明提供了一种结合溶液，它由磷酸盐结合化合物、酸和金属离子组成，其中金属离子同时与目标分子上暴露的磷酸基团和磷酸盐结合化合物的金属螯合基团相互作用，在磷酸盐结合化合物和磷酸化目标分子之间形成桥梁，形成三元复合物。本发明的结合溶液可用于结合和检测固定化和溶解化的磷酸化目标分子，从复合物混合物中分离磷酸化目标分子，以及协助蛋白质组分析，从而鉴定激酶和磷酸酶底物和酶。
• COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES
  申请人：AGNEW Brian

  公开号：US20070054304A1

  公开（公告）日：2007-03-08

  The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.
• NON-INVASIVE SENSING OF FREE METAL IONS USING ION CHEMICAL EXCHANGE SATURATION TRANSFER
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20160091443A1

  公开（公告）日：2016-03-31

  The invention features a novel non-invasive approach for imaging, detecting and/or sensing metal ions with improved sensitivity and specificity in a biological sample or tissue. In certain embodiments, the invention provides a MR contrast-based approach for imaging, detecting and/or sensing metal ions in the biological sample/tissue containing various background ions by using 19F-based chemical exchange saturation transfer (CEST) technique.
• US5516911A
  申请人：——

  公开号：US5516911A

  公开（公告）日：1996-05-14