1,1-Dimethylethyl N-(1-aminocyclohexyl)carbamate | 1092352-64-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,1-Dimethylethyl N-(1-aminocyclohexyl)carbamate
• 英文别名: tert-butyl N-(1-aminocyclohexyl)carbamate
• CAS: 1092352-64-1
• 化学式: C₁₁H₂₂N₂O₂
• 分子量: 214.3
• InChiKey: WRMGZHLPVAVXQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PYRAZINE KINASE INHIBITORS
  申请人：Portola Pharmaceuticals, Inc.

  公开号：US20130131040A1

  公开（公告）日：2013-05-23

  Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

  提供了用于抑制Syk激酶的吡嗪化合物，用于制备这些化合物的中间体，它们的制备方法，药物组合物，抑制Syk激酶活性的方法，以及治疗至少在一定程度上由Syk激酶活性介导的疾病的方法。
• SYNTHETIC RECEPTORS, LIBRARIES AND USES THEREOF
  申请人：——

  公开号：US20030104360A1

  公开（公告）日：2003-06-05

  The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and may independently be straight chain, cyclic or branched. The template may be linked to an identifier which uniquely defines the synthetic receptor. The identifier is a stable chemical molecule or a plurality of stable chemical molecules distinguishable and detectable to picomolar levels or may be an oligonucleotide. In a preferred embodiment, the template is covalently linked to a solid support which is linked to an identifier. In addition, the invention includes methods of preparing synthetic receptors and synthetic receptor libraries. The synthetic library may be linked with identifiers such that the library comprises a plurality of different synthetic receptor members. The invention also provides methods for assaying a synthetic receptor library to determine suitable synthetic receptor(s) which (a) bind an acceptor molecule; (b) exhibit biological activity; (c) which catalyze a reaction or inhibit a catalyzed reaction; and (d) separate compounds in chromatography.

  本发明涉及合成受体，其包括一个多功能有机模板，与两个或更多寡聚物共价连接，这些寡聚物可以独立地相同或不同，并且可以独立地为直链、环状或支链。该模板可以与一个标识符连接，该标识符唯一定义合成受体。标识符是一个稳定的化学分子或多个稳定的化学分子，可以区分和检测到皮克摩尔级别，或者可以是寡核苷酸。在一种首选实施例中，该模板与固体支持体共价连接，该固体支持体与标识符连接。此外，本发明还包括制备合成受体和合成受体库的方法。合成库可以与标识符连接，使库包括多个不同的合成受体成员。本发明还提供了一种测定合成受体库以确定适合的合成受体的方法，这些合成受体可以(a)结合受体分子；(b)表现生物活性；(c)催化反应或抑制催化反应；以及(d)在色谱分离化合物中。
• Pyrazine Kinase Inhibitors
  申请人：Portola Pharmaceuticals, Inc.

  公开号：US20140309209A1

  公开（公告）日：2014-10-16

  Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

  提供了吡嗪化合物，用于抑制Syk激酶，用于制备这些化合物的中间体，其制备方法，药物组合物，用于抑制Syk激酶活性的方法，以及用于治疗至少部分由Syk激酶活性介导的疾病的方法。
• PYRIDYLPHENOL COMPOUND AND USE THEREOF
  申请人：Sasaki Satoshi

  公开号：US20090156646A1

  公开（公告）日：2009-06-18

  The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula —X-R 1 wherein X represents a bond or a spacer, and R 1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R 2 represents an optionally substituted homocyclic or heterocyclic group; and R 3 and R 4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.

  本发明提供了一种具有转移素受体拮抗活性的化合物，可用于预防和治疗激素依赖性癌症、良性前列腺增生、子宫内膜异位症、早熟、子宫肌瘤等。更具体地，本发明提供了一种化合物，其表示为以下公式：或其盐、前药及含有该化合物的药物制剂；其中环A表示一个5-至8-成员的同环或异环族群，可选地具有除公式—X-R1以外的取代基，其中X表示键或空间组分，而R1表示可选地取代的氨基或可选地取代的含氮杂环族群；环B表示可选地取代的苯环；R2表示可选地取代的同环或异环族群；而R3和R4独立地表示氢原子、氰基、酰基或可选地取代的碳氢基团。
• EP0739486A4
  申请人：——

  公开号：EP0739486A4

  公开（公告）日：1998-09-09