蛙皮素九肽 | 55750-00-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 蛙皮素九肽
• 英文名称: H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
• 英文别名: bombesin-(6-14)；(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]pentanediamide
• CAS: 55750-00-0
• 化学式: C₄₇H₇₁N₁₅O₁₁S
• 分子量: 1054.24
• InChiKey: XXFIWKDBCZWORZ-YQZUKWOLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  74
• 可旋转键数：
  32
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  458
• 氢给体数：
  14
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  蛙皮素九肽 、 bombesin
  参考文献：
  名称：

  KURANOVA, I. L.;CHURKINA, S. I.;LYUDMIROVA, V. L.;FILONOVA, E. B.;MUTULIS+, BIOORGAN. XIMIYA, 15,(1989) N, S. 748-762

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 蛙皮素九肽
  参考文献：
  名称：

  Bello, Carlo Di; Lucchiari, Adriana; Buso, Orfeo, Gazzetta Chimica Italiana, 1986, vol. 116, # 5, p. 221 - 228

  摘要：

  DOI：

文献信息

• KURANOVA, I. L.;CHURKINA, S. I.;LYUDMIROVA, V. L.;FILONOVA, E. B.;MUTULIS+, BIOORGAN. XIMIYA, 15,(1989) N, S. 748-762
  作者：KURANOVA, I. L.、CHURKINA, S. I.、LYUDMIROVA, V. L.、FILONOVA, E. B.、MUTULIS+

  DOI：——

  日期：——
• GASTRIN RELEASING PEPTIDE COMPOUNDS
  申请人：Bracco Imaging S.p.A

  公开号：EP2291075A2

  公开（公告）日：2011-03-09
• [EN] GASTRIN RELEASING PEPTIDE COMPOUNDS<br/>[FR] COMPOSÉS PEPTIDIQUES LIBÉRANT DE LA GASTRINE
  申请人：BRACCO IMAGING SPA

  公开号：WO2009143101A2

  公开（公告）日：2009-11-26

  Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means.
• Bello, Carlo Di; Lucchiari, Adriana; Buso, Orfeo, Gazzetta Chimica Italiana, <hi>1986</hi>, vol. 116, # 5, p. 221 - 228
  作者：Bello, Carlo Di、Lucchiari, Adriana、Buso, Orfeo

  DOI：——

  日期：——