(R)-1-(2-Bromo-acetyl)-pyrrolidine-2-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-1-(2-Bromo-acetyl)-pyrrolidine-2-carboxylic acid methyl ester
• 英文别名: methyl (2R)-1-(2-bromoacetyl)pyrrolidine-2-carboxylate
• 化学式: C₈H₁₂BrNO₃
• 分子量: 250.092
• InChiKey: HRDFBVJXJFDTHU-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-1-(2-Bromo-acetyl)-pyrrolidine-2-carboxylic acid methyl ester 生成 glycolyl-(d)-proline pyrophosphate tetralithium salt
  参考文献：
  名称：

  Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog

  摘要：

  Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that are potent inhibitors of the enzyme. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00374-5
• 作为产物：
  描述：

  溴乙酰氯 、 D-脯氨酸甲酯盐酸盐 在 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 (R)-1-(2-Bromo-acetyl)-pyrrolidine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog

  摘要：

  Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that are potent inhibitors of the enzyme. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00374-5