3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-N-methylpropan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-N-methylpropan-1-amine
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.29
• InChiKey: ZHNOMAALXCJCCQ-AOOOYVTPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3277682B1

  公开（公告）日：2019-04-24
• [EN] 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS DE LA 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PI3K
  申请人：DAIICHI SANKYO CO LTD

  公开号：WO2016157074A1

  公开（公告）日：2016-10-06

  The present invention relates to a pyrazole derivative of formula (I), a 5 pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, stereoisomer thereof or a deuterium form thereof, wherein, n, Y, Ra, R1, R2, R3, R4, R5 and R6 are as defined hereinafter in the specification, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. formula (I) Particularly, the present invention provides a compound of formula (I) as inhibitors of phosphatidylinositol-3-kinase (PI3K), which can be used for treating or preventing inflammatory, autoimmune, orphan and hyperproliferative disease and disorder.