Lopac-G-7788

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Lopac-G-7788
• 英文别名: (2R)-2-(diaminomethylideneamino)pentanedioic acid
• 化学式: C₆H₁₁N₃O₄
• 分子量: 189.17
• InChiKey: RHVVRMJOHATSPD-GSVOUGTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• PARAKERATOSIS INHIBITOR, PORE SHRINKING AGENT OR AGENT FOR PREVENTING OR IMPROVING ROUGH SKIN, AND COMPOSITION FOR EXTERNAL USE ON THE SKIN CONTAINING THE SAME
  申请人：Shiseido Company, Ltd.

  公开号：EP2255780A1

  公开（公告）日：2010-12-01

  The present invention provides a parakeratosis inhibitor, a pore-shrinking agent, and a rough skin inhibiting or ameliorating agent comprising, as an active ingredient, a compound that has excellent effects and high safety without safety problems such as sensory irritation, and provides an external composition for skin containing the same. The compound is selected from the glutamic acid derivatives represented by formula (1) or (2) and the salts thereof: wherein A represents a carbamoyl group, a benzyloxycarbonyl group, an alkyl group having 1 to 3 carbon atoms, an allyl group, or an amidino group; wherein Z represents an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, etc.; Y represents OH, an alkyloxy group having 1 to 3 carbon atoms, an allyloxy group, or NR3R4; R1 to R4 each independently represents H, an alkyl group having 1 to 3 carbon atoms, an allyl group, a cycloalkyl group having 3 to 7 carbon atoms, a cycloalkenyl group having 3 to 7 carbon atoms, a phenyl group, or a benzyl group, or R1 and R2, or R3 and R4, independently form a heterocycle.

  本发明提供了一种角化抑制剂、毛孔收缩剂和皮肤粗糙抑制或改善剂，其活性成分包括一种效果优异、安全性高且不存在感官刺激等安全问题的化合物，并提供了一种含有该化合物的皮肤外用组合物。该化合物选自式（1）或（2）代表的谷氨酸衍生物及其盐类： 其中 A 代表氨基甲酰基、苄氧羰基、具有 1 至 3 个碳原子的烷基、烯丙基或脒基； 其中 Z 代表具有 1 至 4 个碳原子的烷基、具有 2 至 4 个碳原子的烯基等。R1 至 R4 各自独立地代表 H、具有 1 至 3 个碳原子的烷基、烯丙基、具有 3 至 7 个碳原子的环烷基、具有 3 至 7 个碳原子的环烯基、苯基或苄基，或 R1 和 R2 或 R3 和 R4 独立地形成杂环。
• Parakeratosis Inhibitor, Pore-Shrinking Agent, Or Rough Skin Inhibiting/Ameliorating Agent, And External Composition For Skin Containing The Same
  申请人：Iida Toshii

  公开号：US20110004019A1

  公开（公告）日：2011-01-06

  The present invention provides a parakeratosis inhibitor, a pore-shrinking agent, and a rough skin inhibiting or ameliorating agent comprising, as an active ingredient, a compound that has excellent effects and high safety without safety problems such as sensory irritation, and provides an external composition for skin containing the same. The compound is selected from the glutamic acid derivatives represented by formula (1) or (2) and the salts thereof: wherein A represents a carbamoyl group, a benzyloxycarbonyl group, an alkyl group having 1 to 3 carbon atoms, an allyl group, or an amidino group; wherein Z represents an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, etc.; Y represents OH, an alkyloxy group having 1 to 3 carbon atoms, an allyloxy group, or NR 3 R 4 ; R 1 to R 4 each independently represents H, an alkyl group having 1 to 3 carbon atoms, an allyl group, a cycloalkyl group having 3 to 7 carbon atoms, a cycloalkenyl group having 3 to 7 carbon atoms, a phenyl group, or a benzyl group, or R 1 and R 2 , or R 3 and R 4 , independently form a heterocycle.