(S)-6-((1-Carbamoylcyclohexyl)amino)-6-oxo-5-((S)-6-((E)-3-(pyridin-3-yl)acrylamido)-2-(2-(4-(3-(o-tolyl)ureido)phenyl)acetamido)hexanamido)hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-6-((1-Carbamoylcyclohexyl)amino)-6-oxo-5-((S)-6-((E)-3-(pyridin-3-yl)acrylamido)-2-(2-(4-(3-(o-tolyl)ureido)phenyl)acetamido)hexanamido)hexanoic acid
• 英文别名: (5S)-6-[(1-carbamoylcyclohexyl)amino]-5-[[(2S)-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]-6-[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]hexanoyl]amino]-6-oxohexanoic acid
• 化学式: C₄₃H₅₄N₈O₈
• 分子量: 810.9
• InChiKey: OOYFOUHICCOHRQ-CVLSMVSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  59
• 可旋转键数：
  21
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  251
• 氢给体数：
  8
• 氢受体数：
  9

文献信息

• SYSTEMIC AND LOCAL EX VIVO GENE THERAPY OF THE SKELETON
  申请人：The United States Government as represented by the Department of Veterans Affairs

  公开号：US20160120944A1

  公开（公告）日：2016-05-05

  Methods are disclosed herein for increasing bone mass and strength or bone fracture healing in a subject. The methods include administering to the subject a therapeutically effective amount of multipotent stem cells, wherein each multipotent stem cell is transformed with a recombinant nucleic acid molecule comprising a heterologous promoter operably linked to a nucleic acid encoding platelet derived growth factor (PDGF) B, and wherein the multipotent stem cells express a sufficient amount of PDGFB to increase bone mass and strength or bone fracture healing. A lentiviral vector also is disclosed that includes a phosphoglycerate kinase-1 (PGK) promoter operably linked to a nucleic acid encoding PDGFB.
• COMPOSITIONS AND METHODS FOR MEASURING CELLULAR MECHANICAL STRESS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20170016885A1

  公开（公告）日：2017-01-19

  Provided are compositions and methods employing cells encapsulated within and attached to a hydrogel, e.g., for measuring mechanical strain and/or stress of the cell and for investigating the mechano-chemo-transduction mechanisms at cellular and molecular levels.
• PEPTIDES FOR ACTIVATION OF CELL SIGNALING IN OSTEOPROGENITOR CELLS
  申请人：The Regents of the University of California

  公开号：US20210395302A1

  公开（公告）日：2021-12-23

  The present invention provides compounds and pharmaceutical compositions of peptidomimetic ligands. The peptidomimetic ligands can be conjugated with phosphonate drugs. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α 4 β 1 integrin on mesenchymal stem cells and for the surface of bone.
• US7576175B2
  申请人：——

  公开号：US7576175B2

  公开（公告）日：2009-08-18
• US9789162B2
  申请人：——

  公开号：US9789162B2

  公开（公告）日：2017-10-17