7-[(1S,2S,3R,4R)-3-[(3S)-3-hydroxyoct-1-enyl]-5-oxabicyclo[2.2.1]heptan-2-yl]-5-heptenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-[(1S,2S,3R,4R)-3-[(3S)-3-hydroxyoct-1-enyl]-5-oxabicyclo[2.2.1]heptan-2-yl]-5-heptenoic acid
• 英文别名: 7-[(1R,4S,5S,6R)-6-[(3S)-3-hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid
• 化学式: C₂₁H₃₄O₄
• 分子量: 350.5
• InChiKey: LQANGKSBLPMBTJ-LCWAXJCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Treatment of vascular complications of diabetes
  申请人：Apeptico Forschung Und Entwicklung Gmbh

  公开号：EP2397151A1

  公开（公告）日：2011-12-21

  A peptide consisting of 7-17 amino acids and including the adjacent hexamer TX1EX2X3E, where X1, X2 and X3 can be any natural or non natural amino acid, wherein the peptide does not exhibit TNF-receptor-binding activity and is cyclic, for the treatment or prevention of vascular complications in diabetes patients.

  一种肽，由 7-17 个氨基酸组成，包括相邻的六聚体 TX1EX2X3E，其中 X1、X2 和 X3 可以是任何天然或非天然氨基酸，其中该肽不显示 TNF 受体结合活性，并且是环状的，用于治疗或预防糖尿病患者的血管并发症。
• Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use
  申请人：The Regents of the University of California

  公开号：US11173146B2

  公开（公告）日：2021-11-16

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.

  苯并噁唑和吲哚类 KCa3.1 激活剂，以及此类化合物在人类或动物身上的治疗用途及其在器官或组织体外保存中的用途。
• Devices and Methods for Determining the Platelet Function in a Centrifugal Analyzer
  申请人：Endermann Joerg

  公开号：US20120237960A1

  公开（公告）日：2012-09-20

  The invention lies in the field of platelet function diagnostics and relates to devices and methods for determining the platelet function in a centrifugal analyzer.
• SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE
  申请人：The Regents of the University of California

  公开号：US20170056376A1

  公开（公告）日：2017-03-02

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.
• US9205424B2
  申请人：——

  公开号：US9205424B2

  公开（公告）日：2015-12-08