5-Chloro-2-(4-piperidinyloxy)benzonitrile | 367501-27-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-Chloro-2-(4-piperidinyloxy)benzonitrile
• 英文别名: 5-chloro-2-piperidin-4-yloxybenzonitrile
• CAS: 367501-27-7
• 化学式: C₁₂H₁₃ClN₂O
• 分子量: 236.7
• InChiKey: QWRYSXWYAHOJPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  45
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Chemical compounds
  申请人：Rigby Aaron

  公开号：US20050171092A1

  公开（公告）日：2005-08-04

  The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

  本发明提供了一个式子(I)的化合物：其中变量在此定义；以及制备这种化合物的过程；以及在治疗趋化因子（例如CCR3）或H1介导的疾病状态中使用这种化合物的用途。
• ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS
  申请人：Yamagishi Tatsuya

  公开号：US20120232052A1

  公开（公告）日：2012-09-13

  The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar 1 is phenyl; Ar 2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO 2 —, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

  本发明涉及公式（I）的芳基羧酰胺衍生物，其中Ar1是苯基；Ar2是芳基；n为1-4；X为—O—、—S—、—SO—或—SO2—，其前体药物或其药学上可接受的盐，具有阻断电压门控钠通道如TTX-S通道的活性，并在治疗或预防涉及电压门控钠通道的疾病和疾病，如疼痛方面中有用。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病和疾病，如疼痛方面的使用。
• SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20150111922A1

  公开（公告）日：2015-04-23

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R 1 , R 2 , R 3 and R 4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.

  本发明提供了公式（I）的化合物及其药学上可接受的盐：（I）其中m、n、W、X、Y、Z、R1、R2、R3和R4如规范中所定义，用于治疗或预防由前动力素介导的疾病或情况，例如精神和神经疾病。
• Substituted bipiperidine intermediates and derivatives thereof
  申请人：AstraZeneca AB

  公开号：EP1493743A1

  公开（公告）日：2005-01-05

  A compound of formula (Xllla): wherein: L2 is hydrogen, tert-butoxycarbonyl or benzyl; t is 0 or 1; m and p are, independently, 0, 1 or 2; X is CH2, C(O), O, S, S(O), S(O)2 or NR37; provided that when m and p are both 1 then X is not CH2; and R1 has specified values.

  一种式(Xllla)化合物： 其中L2 是氢、叔丁氧基羰基或苄基；t 是 0 或 1；m 和 p 分别是 0、1 或 2；X 是 CH2、C(O)、O、S、S(O)、S(O)2 或 NR37；但当 m 和 p 均为 1 时，X 不是 CH2；R1 具有指定值。
• INTERMEDIATES FOR THE PREPARATION OF PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1604982A1

  公开（公告）日：2005-12-14

  The invention provides a compound of formula (X) or (XVIII): wherein: R1 is optionally substituted aryl or optionally substituted heterocyclyl; and R2 is hydrogen or C1-6 alkyl; said compounds can be used for preparing modulators of chemokine (especially CCR3) activity.

  本发明提供了一种式 (X) 或 (XVIII) 的化合物： 其中R1是任选取代的芳基或任选取代的杂环基；R2是氢或C1-6烷基；所述化合物可用于制备趋化因子（尤其是CCR3）活性调节剂。