2-(Allyloxymethyl)morpholine | 161178-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(Allyloxymethyl)morpholine
• 英文别名: 2-(prop-2-enoxymethyl)morpholine
• CAS: 161178-22-9
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: VFJOGPSADZYRIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5-dioxo-2-(4-nitrobenzoxycarbonylamino)dibenzothiophene 、 2-(Allyloxymethyl)morpholine 生成
  参考文献：
  名称：

  Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor

  摘要：

  式(I)的化合物： 其中： X是式(A)或(B)的基团： 而R1、R2、R3、R4、n、x、y和z的定义如所述。 还描述了它们的制备过程以及它们在治疗由神经肽Y5受体介导的疾病中的用途，如在温血动物，如人类中的用途。

  公开号：

  US20030225097A1

文献信息

• Morpholine derivative
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US05521180A1

  公开（公告）日：1996-05-28

  A morpholine derivative represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group; R.sup.2 represents a halogen atom; and the dotted line indicates an optional double bond. These compounds exhibit a selective 5-HT reuptake inhibitory activity and a selective 5-HT.sub.2 receptor antagonistic activity and useful as a therapeutic agent for depression, anxiety, etc. with reduced side effects.

  一种由式(I)表示的吗啡啶衍生物或其药学上可接受的盐：##STR1## 其中R.sup.1和R.sup.3，可以相同也可以不同，分别代表氢原子或较低的烷基；R.sup.2代表卤原子；虚线表示可选的双键。这些化合物表现出选择性5-HT再摄取抑制活性和选择性5-HT.sub.2受体拮抗活性，并可用作治疗抑郁症、焦虑等疾病的治疗剂，具有减少副作用的作用。
• Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
  申请人：Block Howard Michael

  公开号：US20050209233A1

  公开（公告）日：2005-09-22

  Compounds of formula (I): wherein: X is a group of formula (B): and R 1 , R 2 , R 4 , n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.

  本文描述了化学式（I）的化合物：其中X是化学式（B）的基团，并且R1、R2、R4、n、x、y和z的定义如所述。还描述了它们的制备过程以及它们在治疗温血动物（如人类）中由神经肽Y5受体介导的疾病中的应用。
• MORPHOLINE DERIVATIVE
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0684237A1

  公开（公告）日：1995-11-29

  A morpholine derivative represented by general formula (I) or salt thereof, wherein R¹ and R³ may be the same or different from each other and each represents hydrogen or lower alkyl; R² represents halogen, and the broken line represents an optional double bond. The compound and salts thereof have the activities of both of a 5-HT reincorporation inhibitor and a 5-HT₂ receptor antagonist and are useful as a therapeutic agent reduced in the side effects such as depression and anxiety.

  由通式(I)代表的吗啉衍生物或其盐，其中R¹和R³可以彼此相同或不同，各自代表氢或低级烷基；R²代表卤素，断线代表任选双键。该化合物及其盐类同时具有 5-HT 重归并抑制剂和 5-HT₂ 受体拮抗剂的活性，可作为治疗剂减少抑郁和焦虑等副作用。
• AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR
  申请人：AstraZeneca AB

  公开号：EP1278739A1

  公开（公告）日：2003-01-29
• US5521180A
  申请人：——

  公开号：US5521180A

  公开（公告）日：1996-05-28