申请人:Hokuriku Pharmaceutical Co., Ltd.
公开号:US04983633A1
公开(公告)日:1991-01-08
Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.
化合物的化学式(I)表示的酰胺化合物:其中R.sub.1代表氢、较低的烷氧基、羟基、较低的烷基、卤素、氨基,可以被较低的烷基、硝基、氰基、磺胺酰取代,R.sub.2代表氢、较低的烷氧基、羟基、较低的烷基、卤素、氨基、硝基,其中R.sub.1和R.sub.2可以组合形成亚甲二氧基,R.sub.3表示氢、较低的烷基、卤素或氨基,R.sub.4和R.sub.5可以相同也可以不同,每个代表较低的烷基或其中R.sub.4和R.sub.5可以与氮一起组合形成1-吡咯啉基或哌啶基,以及其药理学上可接受的酸盐,它们在激活胃运动功能方面表现出优异效果,公开了一种制备药物组合物的方法,以及一种通过将这种化合物给予所述患有胃运动功能不足症状的受试者治疗的方法。