N-[3-chloro-2-(2-methoxy-phenyl)-4-oxoazetidin-1yl]isonicotinamide | 1262213-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: N-[3-chloro-2-(2-methoxy-phenyl)-4-oxoazetidin-1yl]isonicotinamide
• 英文别名: N-[3-chloro-2-(2-methoxyphenyl)-4-oxoazetidin-1-yl]pyridine-4-carboxamide
• CAS: 1262213-03-5
• 化学式: C₁₆H₁₄ClN₃O₃
• 分子量: 331.758
• InChiKey: DLWPVZSHRHJPQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  isonicotinic acid (2-methoxy-benzylidene)-hydrazide 、 氯乙酰氯 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以70%的产率得到N-[3-chloro-2-(2-methoxy-phenyl)-4-oxoazetidin-1yl]isonicotinamide
  参考文献：
  名称：

  Design and synthesis of novel N-substituted-3-chloro-2-azetidinone derivatives as potential anticonvulsant agents

  摘要：

  A new series of N-[3-chloro-2-(substitutedphenyl)-4-oxo-azetidin-1-yl]isonicotinamide (2a-l) were synthesized through condensation reaction of isoniazide with substituted aldehyde. The newly synthesized compounds were characterized by spectral data (IR, (1)H NMR, mass spectra) and elemental analysis. Compound 2e exhibited excellent anticonvulsant activity and no neurotoxicity in comparison to reference drug phenytoin.

  DOI：

  10.1007/s00044-010-9485-0

文献信息

• Design and synthesis of novel N-substituted-3-chloro-2-azetidinone derivatives as potential anticonvulsant agents
  作者：Hozaifa Hasan、Maymoona Akhter、Wasim Akhter、Israr Ali、Mohd. Zaheen、Iftikhar Ahsan、Danish Mahmood

  DOI：10.1007/s00044-010-9485-0

  日期：2011.11

  A new series of N-[3-chloro-2-(substitutedphenyl)-4-oxo-azetidin-1-yl]isonicotinamide (2a-l) were synthesized through condensation reaction of isoniazide with substituted aldehyde. The newly synthesized compounds were characterized by spectral data (IR, (1)H NMR, mass spectra) and elemental analysis. Compound 2e exhibited excellent anticonvulsant activity and no neurotoxicity in comparison to reference drug phenytoin.