4-Methyl-L-lysine | 34200-94-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Methyl-L-lysine
• 英文别名: (2S)-2,6-diamino-4-methylhexanoic acid
• CAS: 34200-94-7
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.21
• InChiKey: NNIFTGRSDICEMZ-GDVGLLTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] HIV PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTÉASE DU VIH
  申请人：MERCK & CO INC

  公开号：WO2009042093A1

  公开（公告）日：2009-04-02

  Compounds of Formula I are disclosed: (I), wherein XA, k, R1, R2, R3, R4, R5, R5A, R6, R6A, R7 and R8 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  已披露的I式化合物：(I)，其中XA、k、R1、R2、R3、R4、R5、R5A、R6、R6A、R7和R8在此定义。公式I所包括的化合物包括HIV蛋白酶抑制剂和其他可在体内代谢为HIV蛋白酶抑制剂的化合物。这些化合物及其药用盐可用于预防或治疗HIV感染以及预防、治疗或延缓艾滋病的发作。这些化合物及其盐可用作药物组成部分，可选择性地与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。
• A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY HAVING A PATHWAY OF GLYCOGEN BIOSYNTHESIS DISRUPTED
  申请人：Rybak Vyacheslavovich Konstantin

  公开号：US20060160192A1

  公开（公告）日：2006-07-20

  There is provided a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea , having the glycogen biosynthesis pathway disrupted.

  提供了一种利用Enterobacteriaceae家族的细菌，特别是属于Escherichia或Pantoea属的细菌，其糖原生物合成途径被破坏，制备L-氨基酸的方法。
• Method of producing target substance by fermentation
  申请人：AJINOMOTO CO., INC

  公开号：US20020155556A1

  公开（公告）日：2002-10-24

  In a method for producing a target substance by utilizing a microorganism comprising culturing a bacterium belonging to the genus Escherichia in a medium to produce and accumulate the target substance in the medium or cells of the bacterium and collecting the target substance, a strain in which an RMF protein does not function normally in its cell due to, for example, disruption of rmf gene on chromosome, is used to improve production efficiency or production rate of a useful substance such as L-amino acid, protein and nucleic acid.

  一种利用微生物生产目标物质的方法，包括培养属于大肠杆菌属的细菌在培养基中，使目标物质在培养基或细菌细胞中产生和积累，然后收集目标物质。使用一种菌株，其细胞中RMF蛋白由于染色体上的rmf基因破坏等原因不能正常发挥作用，以提高有用物质（如L-氨基酸、蛋白质和核酸）的生产效率或生产速率。
• Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family With Attenuated Expression of the KefB Gene
  申请人：Filippov Dmitriy Vladimirovich

  公开号：US20090226980A1

  公开（公告）日：2009-09-10

  The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea , which has been modified to attenuate expression of the kefB gene.

  本发明提供了一种利用肠杆菌科细菌，特别是属于大肠杆菌属或泛东亚杆菌属的细菌，通过调节kefB基因表达来生产L-氨基酸的方法。
• METHOD FOR PRODUCING AN L-AMINO ACID BY FERMENTATION USING A BACTERIUM HAVING AN ENHANCED ABILITY TO UTILIZE GLYCEROL
  申请人：Rybak Konstantin Vyacheslavovich

  公开号：US20090317876A1

  公开（公告）日：2009-12-24

  The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea , which has been modified to have glycerol kinase in which feedback inhibition by fructose-1,6-bisphosphate is desensitized, thereby having enhanced ability to utilize glycerol.

  本发明提供了一种利用肠杆菌科细菌，特别是属于大肠杆菌属或潘托伊属的细菌，通过改良其甘油激酶以减弱果糖-1,6-二磷酸的反馈抑制，从而增强利用甘油的能力，生产L-氨基酸的方法。