[4-(二甲氨基)苯基]-(4-羟基苯基)甲酮 | 102827-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [4-(二甲氨基)苯基]-(4-羟基苯基)甲酮
• 英文名称: (4-(dimethylamino)phenyl)(4-hydroxyphenyl)methanone
• 英文别名: 4-dimethylamino-4'-hydroxy-benzophenone；4-Dimethylamino-4'-hydroxy-benzophenon；4-hydroxy-4'-dimethylaminobenzophenone；Methanone, [4-(dimethylamino)phenyl](4-hydroxyphenyl)-；[4-(dimethylamino)phenyl]-(4-hydroxyphenyl)methanone
• CAS: 102827-03-2
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.29
• InChiKey: WOXJBHQBQQJRFA-UHFFFAOYSA-N

物化性质

• 熔点：
  200°C
• 沸点：
  431.8±30.0 °C(Predicted)
• 密度：
  1.182±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [4-(二甲氨基)苯基]-(4-羟基苯基)甲酮 在 甲酸 、 六氟异丙醇 、 C₁₈H₂₄ClIrN₃⁽¹⁺⁾*Cl^(1-) 、 水 作用下， 以97%的产率得到4-(4-(dimethylamino)benzyl)phenol
  参考文献：
  名称：

  铱作为甲酸的痕量氢化物供体在铱上催化酮的还原性脱氧

  摘要：

  以甲酸为氢化物供体，水为助溶剂，实现了铱催化的酮和醛的脱氧。在低催化剂负载下，许多4-（N，N-二取代氨基）芳基酮易于脱氧，具有出色的收率和化学选择性。许多官能团，尤其是酚羟基和醇羟基，仲胺，羧酸和烷基氯，都具有良好的耐受性。当使用DCO 2 D和D 2 O代替它们的氢化对应物时，可获得双歧化的双链烷烃达90％。激活4‐（N，N已证明二取代氨基）芳基会经历各种有用的转化。脱氧氘已用于制备氘代药物分子Chlorambucil-4,4- d 2。

  DOI：

  10.1002/adsc.202000821
• 作为产物：
  描述：

  [4-(二甲基氨基)苯基](4-甲氧基苯基)-甲酮 在 aluminum tri-bromide 、 苯 作用下， 生成 [4-(二甲氨基)苯基]-(4-羟基苯基)甲酮
  参考文献：
  名称：

  Pfeiffer; Loewe, Journal fur praktische Chemie (Leipzig 1954), 1937, vol. <2> 147, p. 293,303

  摘要：

  DOI：

文献信息

• [EN] PHOTOINITIATORS FUNCTIONED AS BOTH INITIATORS AND NANOFILLERS<br/>[FR] PHOTO-INITIATEURS FONCTIONNANT À LA FOIS EN TANT QU'INITIATEURS ET NANOCHARGES
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2017030504A1

  公开（公告）日：2017-02-23

  This invention relates to a photoinitiator compound comprising: a polyhedral oligomeric silsesquioxane (POSS) moiety and a photoinitiator moiety, wherein the photoinitiator compound having the structure according to formula (I): [R-SiO1.5]n (I), wherein n is 6, 8, 10 or 12 and R is independently selected from the group consisting of H, linear or branched (hetero)alkyl, linear or branched (hetero)alkenyl, (hetero)aryl, (hetero)alkyl aryl, (hetero)aryl alkyl and a photoinitiator moiety, wherein at least one R is a photoinitiator moiety and the photoinitiator compound is a nanoparticle. The present invention also relates to a method for the production of the photoinitiator compound of the invention, a photopolymerizable composition comprising the photoinitiator compound of the invention, the use of the photoinitiator compound of the invention for photopolymerization. The present invention is further related to a coated substrate comprising the photopolymerizable composition of the invention.

  本发明涉及一种光引发剂化合物，包括：多面体寡聚硅氧烷（POSS）基团和光引发剂基团，其中所述光引发剂化合物具有以下结构的结构（I）：[R-SiO1.5]n（I），其中n为6、8、10或12，R独立地选自H、线性或支链（杂）烷基、线性或支链（杂）烯基、（杂）芳基、（杂）烷基芳基、（杂）芳基烷基和光引发剂基团的组，其中至少一个R是光引发剂基团，且所述光引发剂化合物是一种纳米粒子。本发明还涉及一种制备所述光引发剂化合物的方法，一种包括所述光引发剂化合物的光聚合组合物，以及利用所述光引发剂化合物进行光聚合的用途。本发明还涉及包括本发明的光聚合组合物的涂层基材。
• Subcellular Localization and Oligomerization of the Arabidopsis thaliana Somatic Embryogenesis Receptor Kinase 1 Protein
  作者：Khalid Shah、Theodorus W.J. Gadella Jr、Harrie van Erp、Valérie Hecht、Sacco C. de Vries

  DOI：10.1006/jmbi.2001.4706

  日期：2001.6

  The Arabidopsis thaliana somatic embryogenesis receptor kinase 1 (AtSERK1) gene is expressed in developing ovules and early embryos. AtSERK1 is also transiently expressed during somatic embryogenesis. The predicted AtSERK1 protein contains an extracellular domain with a leucine zipper motif followed by five leucine-rich repeats, a proline-rich region, a single transmembrane region and an intracellular

  拟南芥体细胞胚发生受体激酶1（AtSERK1）基因在发育的胚珠和早期胚胎中表达。AtSERK1在体细胞胚发生过程中也瞬时表达。预测的AtSERK1蛋白包含带有亮氨酸拉链基序的细胞外结构域，其后是五个富含亮氨酸的重复序列，一个富含脯氨酸的区域，一个跨膜区域和一个细胞内激酶结构域。AtSERK1 cDNA与绿色荧光蛋白（GFP）的两个不同变体融合，即发黄光的GFP（YFP）和发蓝光的GFP（CFP），并在植物原生质体和昆虫细胞中瞬时表达。使用共聚焦激光扫描显微镜确定，AtSERK1-YFP融合蛋白靶向植物和动物细胞中的质膜。富含细胞亮氨酸的重复序列 特别是存在于它们上的N-连接的寡糖似乎对于AtSERK1-YFP蛋白的正确定位是必不可少的。通过使用荧光光谱成像显微镜测量YFP / CFP荧光发射率，研究了AtSERK1蛋白的二聚化潜力。如果AtSERK1-CFP和AtSERK1-YFP融合蛋白
• Preparation of prodrugs for selective drug delivery
  申请人：Mills L. Randell

  公开号：US20050080260A1

  公开（公告）日：2005-04-14

  Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

  合成具有A-B-C化学式的化合物，可用于药物传递等应用，其中A是化学发光基团，B是光致变色基团，C是生物活性基团，其中A-B-C可作为前药。本发明的新型合成方法用于形成前药，包括以下步骤：(1)形成苯酮，(2)形成二芳基乙烯，(3)将邻苯二甲酰亚胺基团连接到乙烯的至少一个芳基上，形成邻苯二甲酰亚胺-乙烯共轭物，(4)缩合两个乙烯-邻苯二甲酰亚胺共轭物，形成邻苯二甲酰亚胺-戊二烯共轭物，(5)通过与肼反应将邻苯二甲酰亚胺转化为邻苯二酰肼，形成本发明的载体化合物，(6)将载体化合物与药物的亲核基团反应，形成相应的前药。另外，可以通过使用卤代二芳基乙烯制备相应的阳离子类似的类似类似染料化合物。然后，通过与亲核试剂反应保护阳离子类似化合物，并通过钯催化的胺化与氨基邻苯二甲酰亚胺偶联，形成保护的邻苯二甲酰亚胺-戊二烯共轭物。后者与肼回流，将其邻苯二甲酰亚胺转化为邻苯二酰肼，并酸化以得到载体。本发明的另一个方面涉及将这些化合物用作抗病毒剂，用于治疗病毒感染，如HIV，以及用作抗癌剂，用于治疗结肠癌、肺癌和乳腺癌等癌症。
• Radiation-sensitive, ethylenically unsaturated copolymerizable compounds
  申请人：——

  公开号：US05206417A1

  公开（公告）日：1993-04-27

  The ethylenically unsaturated organic compounds are of the general formula ##STR1## where R is alkyl, aryl or a radical R.sup.1, and R.sup.1 is a radical ##STR2## where R.sup.2 to R.sup.6 are each H, alkyl, OH, Oalkyl, SH, Salkyl, halogen, N(alkyl).sub.2 or N(alkyl)(aryl), and not less than one but not more than three of the radicals R.sup.2 to R.sup.6 are each a radical ##STR3## where X is alkylene or oxaalkylene, each of 2 to 10 carbon atoms, and Y is H or CH.sub.3. These compounds have particularly high photochemical reactivity in the medium-wavelength to relatively long-wavelength UV range.

  含有乙烯基不饱和的有机化合物的一般式为##STR1##其中R是烷基、芳基或基团R.sup.1，R.sup.1是基团##STR2##其中R.sup.2至R.sup.6分别为H、烷基、OH、O烷基、SH、S烷基、卤素、N（烷基）.sub.2或N（烷基）（芳基），但R.sup.2至R.sup.6中至少有一个但不超过三个基团为##STR3##其中X为2至10个碳原子的烷基或氧代烷基，Y为H或CH.sub.3。这些化合物在中波至相对长波长的紫外线范围内具有特别高的光化学反应活性。
• Polymeric sensitizers for photopolymer composition
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04565769A1

  公开（公告）日：1986-01-21

  Photopolymerizable composition consisting essentially of (A) at least one ethylenically unsaturated monomeric compound, (B) at least one 2,4,5-triarylimidazolyl dimer, (C) sensitizing amount of at least one polymeric sensitizer, weight average molecular weight 10,000 to 300,000, which is the reaction product of (1) a reactive photosensitizer and (2) a reactive polymer as defined herein, and (D) optionally an organic polymeric binder. The compositions are useful in photoresists, chemical milling, toning films and printing plates.

  光敏聚合物组合物，基本包括(A) 至少一种乙烯基不饱和单体化合物，(B) 至少一种2,4,5-三芳基咪唑二聚体，(C) 至少一种敏化剂的感光量，分子量为10,000至300,000的聚合物敏化剂，其是由(1) 反应性光敏剂和(2) 本文所定义的反应性聚合物的反应产物，以及(D) 可选的有机聚合物粘合剂。该组合物在光阻、化学刻蚀、调色膜和印刷板中有用。