methyl (2S)-3-methyl-2-(4-methylidene-1,1-dioxo-3H-1lambda6,2-benzothiazin-2-yl)butanoate | 1153687-02-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-3-methyl-2-(4-methylidene-1,1-dioxo-3H-1lambda6,2-benzothiazin-2-yl)butanoate
• 英文别名: methyl (2S)-3-methyl-2-(4-methylidene-1,1-dioxo-3H-1λ6,2-benzothiazin-2-yl)butanoate
• CAS: 1153687-02-5
• 化学式: C₁₅H₁₉NO₄S
• 分子量: 309.386
• InChiKey: XACLGIAFDIFMGG-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 palladium diacetate 、 三乙胺 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 methyl (2S)-2-[(2-bromophenyl)sulfonylamino]-3-methylbutanoate 、 、 methyl (2S)-3-methyl-2-(4-methylidene-1,1-dioxo-3H-1lambda6,2-benzothiazin-2-yl)butanoate
  参考文献：
  名称：

  α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams

  摘要：

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.053

文献信息

• α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams
  作者：Dinesh Kumar Rayabarapu、Aihua Zhou、Kyu Ok Jeon、Thiwanka Samarakoon、Alan Rolfe、Hina Siddiqui、Paul R. Hanson

  DOI：10.1016/j.tet.2008.11.053

  日期：2009.4

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.