Fucose, tetraacetate | 109430-94-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fucose, tetraacetate
• 英文别名: [(2R,3S,4S,5R)-3,4,5-triacetyloxy-6-oxohexan-2-yl] acetate
• CAS: 109430-94-6
• 化学式: C₁₄H₂₀O₉
• 分子量: 332.3
• InChiKey: OPVYKVGCFWDTOI-SPEPIWJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• [EN] COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES<br/>[FR] COMPOSÉS ET PROCÉDÉS DE CONJUGAISON DE BIOMOLÉCULES
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2012121973A1

  公开（公告）日：2012-09-13

  Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.

  低铜点击化学，1,3-双极环加成和施陀林反应用于修饰生物分子。涉及低铜点击化学，1,3-双极环加成和施陀林反应的组合物、方法和试剂盒也提供。
• 1,3-DIPOLAR CYCLOADDITIONS, AND STAUDINGER LIGATIONS FOR CONJUGATING BIOMOLECULES USING CLICK CHEMISTRY
  申请人：Bioconjugate Technologies, LLC

  公开号：US20210214338A1

  公开（公告）日：2021-07-15

  Compositions, methods, and kits for the labeling, detecting, isolating and/or analysis of biomolecules modified by attachment of chemical handles are disclosed. These embodiments involve a compound of the formula:

  揭示了用于标记、检测、分离和/或分析通过化学手柄附着的生物分子的组合物、方法和试剂盒。这些实施例涉及以下式的化合物：
• [EN] METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE<br/>[FR] PROCÉDÉ DE PRÉPARATION DU 2'-O-FUCOSYLLACTOSE
  申请人：BASF SE

  公开号：WO2017153452A1

  公开（公告）日：2017-09-14

  The present invention relates to a method for preparing 2'-O-fucosyllactose and to the protected fucosyl donor of the formula (I) used in this method. The method comprises reacting the fucose derivative of the formula (I) below with the compound of the general formula (II), in the presence of an activating reagent. In the formulae (I) and (II), the variables are each defined as follows: X is Br or a S-bound radical, namely -SCN, -S(O)n-RX1 or -S-RX2, wherein RX1 preferably is an optionally substituted phenyl, and RX2 preferably is C1-C4-alkyl, 2-oxazolin-2-yl, 2-thiazolin-2-yl, benzoxazol-2-yl, benzothiazol-2-yl or pyridin-2-yl; RSi are the same or different and are radicals of the formula SiRaRbRc, wherein Ra, Rb and Rc preferably are each methyl; R1 is a C(=O)-R11 radical or an SiR12R13R14 radical, wherein R11 is preferably methyl, phenyl or tert-butyl, and R12, R13 and R14 preferably are each methyl; R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.

  本发明涉及一种制备2'-O-岩藻糖乳酸的方法，以及在该方法中使用的公式（I）的保护岩藻糖供体。该方法包括在活化试剂存在下，将下式（I）的岩藻糖衍生物与通用式（II）的化合物反应。在公式（I）和（II）中，变量的定义如下：X为Br或S-结合基团，即-SCN，-S（O）n-RX1或-S-RX2，其中RX1优选为可选取代的苯基，RX2优选为C1-C4-烷基，2-噁唑烷-2-基，2-噻唑烷-2-基，苯并噁唑烷-2-基，苯并噻唑烷-2-基或吡啶-2-基；RSi相同或不同，且为公式SiRaRbRc的基团，其中Ra，Rb和Rc优选为甲基；R1为C（=O）-R11基团或SiR12R13R14基团，其中R11优选为甲基，苯基或叔丁基，R12，R13和R14优选为甲基；R2相同或不同，为C1-C8烷基，或共同形成线性C3-C6烷二基，其未取代或有1至6个甲基取代基；R3相同或不同，为C1-C8烷基，或共同形成线性C1-C4烷二基，其未取代或有1至6个甲基取代基。
• Compounds and Methods for Conjugation of Biomolecules
  申请人：Gee Kyle

  公开号：US20150072396A1

  公开（公告）日：2015-03-12

  Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.

  提供了用于修饰生物分子的低铜点击化学、1,3-偶极环加成和斯陶丁格配合反应。还提供了与低铜点击化学、1,3-偶极环加成和斯陶丁格配合反应相关的组合物、方法和试剂盒。
• METHOD FOR PRODUCING PYRAZOLES, NOVEL PYRAZOLES AND APPLICATIONS THEREOF
  申请人：COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

  公开号：US20150368295A1

  公开（公告）日：2015-12-24

  A method for preparing a pyrazole of formula (I) in which R,R′ and R″ have different meanings, characterised in that it involves reacting a sydnone of formula (II) in which R and R′ have the meanings already indicated, with an alkyne of formula (III) in which R″ has the meaning already indicated, in the presence of copper, to obtain a pyrazole compound of formula (I) that is then isolated and salified if desired.

  一种制备式（I）的吡唑的方法，其中R、R′和R″具有不同的含义，其特征在于它涉及将式（II）的噻唑啉（其中R和R′已经指示了含义）与式（III）的炔烃（其中R″已经指示了含义）在铜的存在下反应，以获得式（I）的吡唑化合物，然后如有需要进行分离和盐化。