Delmopinol, (S)- | 156407-33-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: Delmopinol, (S)-
• 英文别名: 2-[(3S)-3-(4-propylheptyl)morpholin-4-yl]ethanol
• CAS: 156407-33-9
• 化学式: C₁₆H₃₃NO₂
• 分子量: 271.44
• InChiKey: QSFOWAYMMZCQNF-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHOD FOR THE MANUFACTURING OF DELMOPINOL<br/>[FR] PROCÉDÉ DE PRODUCTION DE DELMOPINOL
  申请人：LUNDBECK PHARMACEUTICALS ITALY S P A

  公开号：WO2018115096A1

  公开（公告）日：2018-06-28

  The present invention relates to a new process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name Delmopinol. The invention also relates to three key intermediates 1-chloro-4- propylhept-3-ene, 1-iodo-4-propylhept-3-ene and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol.

  本发明涉及一种生产2-(3-(4-丙基庚基)吗啡啉)乙基-1-醇（国际非专有名称Delmopinol）的新工艺。该发明还涉及三个关键中间体1-氯-4-丙基庚-3-烯、1-碘-4-丙基庚-3-烯和2-(3-(4-丙基庚-3-烯-1-基)吗啡啉)乙基-1-醇。
• [EN] METHOD FOR THE MANUFACTURING OF 2-(3-(ALKYL AND ALKENYL)MORPHOLINO)-ETHAN-1-OLS<br/>[FR] PROCÉDÉ DE FABRICATION DE 2-(3-(ALKYLE ET ALCÉNYLE)MORPHOLINO)-ÉTHAN-1-OLS
  申请人：LUNDBECK PHARMACEUTICALS ITALY S P A

  公开号：WO2018115111A1

  公开（公告）日：2018-06-28

  The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.

  本发明涉及一种通过还原8a-(烷基和烯基)六氢氧杂氮杂环[2,3-c][1,4]噁嗪，制备2-(3-(烷基或烯基)吗啉基)-乙基-1-醇的方法，包括生产带有INN名称Delmopinol的2-(3-(4-丙基庚基)吗啉基)乙基-1-醇的过程。该发明还涉及1-氯-4-丙基庚-3-烯，1-碘-4-丙基庚-3-烯，8a-(4-5 丙基庚基)六氢氧杂氮杂环[2,3-c][1,4]噁嗪，8a-(4-丙基庚-3-烯-1-基)六氢氧杂氮杂环[2,3-c][1,4]噁嗪和2-(3-(4-丙基庚-3-烯-1-基)吗啉基)乙基-1-醇，这些是Delmopinol过程中的中间体。
• [EN] METHOD FOR THE MANUFACTURING OF DELMOPINOL INTERMEDIATES<br/>[FR] PROCÉDÉ DE FABRICATION D'INTERMÉDIAIRES DE DELMOPINOL
  申请人：LUNDBECK PHARMACEUTICALS ITALY S P A

  公开号：WO2018115116A1

  公开（公告）日：2018-06-28

  The present invention relates to a new process for producing intermediates useful in the manufacture of 2-(3-(4-propylheptyl)morpholino)ethan-l-ol. The invention also relates to intermediates l-chloro-4-propylhept-3-ene and l-iodo-4-propylhept-3-ene.

  本发明涉及一种用于生产2-(3-(4-丙基庚基)吗啉基)乙基-1-醇制造中间体的新工艺。该发明还涉及中间体l-氯-4-丙基庚-3-烯和l-碘-4-丙基庚-3-烯。
• METHOD FOR THE MANUFACTURING OF DELMOPINOL INTERMEDIATES
  申请人：Lundbeck Pharmaceuticals Italy S.p.A.

  公开号：EP3558952A1

  公开（公告）日：2019-10-30
• METHOD FOR THE MANUFACTURING OF 2-(3-(ALKYL AND ALKENYL)MORPHOLINO)-ETHAN-1-OLS
  申请人：Lundbeck Pharmaceuticals Italy S.p.A.

  公开号：EP3558953A1

  公开（公告）日：2019-10-30