2-[2-[Bis(carboxymethyl)amino]ethyl-(2-oxoethyl)amino]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-[Bis(carboxymethyl)amino]ethyl-(2-oxoethyl)amino]acetic acid
• 化学式: C₁₀H₁₆N₂O₇
• 分子量: 276.24
• InChiKey: GRSIKTXTIPKMQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• CHELATING MONOMERS AND POLYMERS
  申请人：Zhang Hongmin

  公开号：US20070254378A1

  公开（公告）日：2007-11-01

  This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.

  本发明提供了包含芳基的螯合基团。包括螯合基团的单体可以聚合成螯合聚合物。螯合聚合物可用于螯合金属。以金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。螯合聚合物可以包含在芯片和色谱材料等物品中。
• PEPTIDE-COMPOUND CYCLIZATION METHOD
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20150080549A1

  公开（公告）日：2015-03-19

  An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

  本发明的目的是提供一种发现对于难以处理的靶点有效的药物的方法，这些药物通常很难被发现。本发明涉及新型的环化肽化合物的方法，以及包含这些化合物的新型肽库，以实现上述目的。
• Ultraviolet ray screening agent
  申请人：TOPY INDUSTRIES LIMITED

  公开号：EP0530810A2

  公开（公告）日：1993-03-10

  The object of the present invention is to provide composite synthetic mica powder having excellent ultraviolet ray screening effect. The composite synthetic mica powder of the present invention is characterized in that a mica fine particle layer (B) containing one or more types of elements selected from a group of Te, Bi, Pb, Ce, Fe, Mo, Nb, W, Sb, Sn, V, Mn, Ni, Co, Zn and Ti is formed on the surface of scale-like mica particles (A), whereby:    covering ratio of said particles (A) by said particles (B) is lower than or equal to 1 and higher than or equal to 0.5; and    ratio of particle size of said particles (B) to plane direction diameter of said particles (A) is lower than or equal to 0.1, and particle size of said particles (A) is 1 to 100 µm. Another object of the present invention is to provide red synthetic mica, which develops light-resistant red color closer to color of human skin and ultraviolet ray, and also to provide a method for manufacturing the same and an ultraviolet ray screening agent containing said synthetic mica. The synthetic mica of the present invention is characterized in that, it is expressed by the following formula (I): X1/3∼1 Y2∼3 (Z₄ O₁₀) F2×0.75∼2×0.99   (I) (where X represents one or more types of ions selected from a group of Na, K, Li, Ca, Rb and Sr, Y represents one or more types of ions selected from a group of Mg, Fe, Ni, Mn, Al, Li, Co, Ti and Zn, Z represents one or more types of ions selected from a group of Al, Si, Ge, Fe, B, Co and Ti, and at least one of Y and Z represents an iron ion), molar number of iron contained in said synthetic mica is 0.01 to 3 mols, and, when said synthetic mica is measured by powder cell method, its color is given by L*=55 to 75, a*=5 to 20, and b*=5 to 20 by the CIE 1976 (L*a*b*) space.

  本发明的目的是提供具有优异紫外线屏蔽效果的复合合成云母粉。 本发明的复合合成云母粉的特征在于，在鳞片状云母颗粒（A）的表面形成含有选自 Te、Bi、Pb、Ce、Fe、Mo、Nb、W、Sb、Sn、V、Mn、Ni、Co、Zn 和 Ti 中的一种或多种元素的云母细颗粒层（B），其中： 所述颗粒（A）与所述颗粒（B）的覆盖率小于或等于 1，大于或等于 0.5；以及 所述颗粒（B）的粒径与所述颗粒（A）的平面方向直径之比低于或等于 0.1，且所述颗粒（A）的粒径为 1 至 100 µm。 本发明的另一个目的是提供红色合成云母，这种云母能产生更接近人体皮肤颜色和紫外线的耐光红色，还提供了制造这种云母的方法和含有所述合成云母的紫外线屏蔽剂。 本发明的合成云母的特征在于，它由下式（I）表示： X1/3∼1 Y2∼3 (Z₄ O₁₀) F2×0.75∼2×0.99 (I) (其中 X 代表选自 Na、K、Li、Ca、Rb 和 Sr 组的一种或多种离子，Y 代表选自 Mg、Fe、Ni、Mn、Al、Li、Co、Ti 和 Zn 组的一种或多种离子，Z 代表选自 Al、Si、Ge、Fe、B、Co 和 Ti 组的一种或多种离子，Y 和 Z 中至少有一个代表铁离子)，所述合成云母中所含铁的摩尔数为 0.当所述合成云母用粉末池法测量时，其颜色由 CIE 1976（L*a*b*）空间给出：L*=55 至 75，a*=5 至 20，b*=5 至 20。
• New red synthetic mica and ultraviolet ray screening agent comprising the same
  申请人：TOPY INDUSTRIES, LIMITED

  公开号：EP0665273A1

  公开（公告）日：1995-08-02

  The object of the present invention is to provide red synthetic mica, which develops light-resistant red color closer to color of human skin and ultraviolet ray, and also to provide a method for manufacturing the same and an ultraviolet ray screening agent containing said synthetic mica. The synthetic mica of the present invention is characterized in that, it is expressed by the following formula (I):         X1/3∼1 Y2∼3 (Z₄ O₁₀) F2×0.75∼2×0.99   (I) (where X represents one or more types of ions selected from a group of Na, K, Li, Ca, Rb and Sr, Y represents one or more types of ions selected from a group of Mg, Fe, Ni, Mn, Al, Li, Co, Ti and Zn, Z represents one or more types of ions selected from a group of Al, Si, Ge, Fe, B, Co and Ti, and at least one of Y and Z represents an iron ion), molar number of iron contained in said synthetic mica is 0.01 to 3 mols, and, when said synthetic mica is measured by powder cell method, its color is given by L* = 55 to 75, a* = 5 to 20, and b* = 5 to 20 by the CIE 1976 (L*a*b*) space.

  本发明的目的是提供一种红色合成云母，它能产生更接近人体皮肤颜色和紫外线的耐光红色，同时还提供一种制造方法和一种含有上述合成云母的紫外线屏蔽剂。 本发明的合成云母的特征在于，它由下式（I）表示： X1/3∼1 Y2∼3 (Z₄ O₁₀) F2×0.75∼2×0.99 (I) (其中 X 代表选自 Na、K、Li、Ca、Rb 和 Sr 组的一种或多种离子，Y 代表选自 Mg、Fe、Ni、Mn、Al、Li、Co、Ti 和 Zn 组的一种或多种离子，Z 代表选自 Al、Si、Ge、Fe、B、Co 和 Ti 组的一种或多种离子，Y 和 Z 中至少有一个代表铁离子)，所述合成云母中所含铁的摩尔数为 0.当用粉末池法测量所述合成云母时，根据 CIE 1976（L*a*b*）空间，其颜色为 L* = 55 至 75，a* = 5 至 20，b* = 5 至 20。
• TRIFUNCTIONAL REAGENT FOR CONJUGATION TO A BIOMOLECULE
  申请人：Department of Radiation Oncology, University of Washington

  公开号：EP1095274B1

  公开（公告）日：2010-09-29