(S)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: (S)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
• 化学式: C₁₉H₂₂N₂O
• 分子量: 294.4
• InChiKey: KMPWYEUPVWOPIM-SIGHOMJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MOLECULE RECOGNITION POLYMER ENABLING RECONSTRUCTION OF RECOGNITION FIELD FOR TARGET MOLECULE AND METHOD OF PRODUCING THE SAME
  申请人：Japan Science and Technology Agency

  公开号：EP1767551A1

  公开（公告）日：2007-03-28

  It is intended to provide a molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which is produced by applying the molecular imprinting method. A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which has a molecule interacting with the target molecule in the polymer and in which the recognition field for a target molecule has been constructed and the above-described molecule interacting with the target molecule is detachable and replaceable. This molecular recognition polymer can be produced by synthesizing a complex of the target molecule with a molecule capable of specifically and reversibly binding to the target molecule, copolymerizing this complex with a molecule interacting with the target molecule and a crosslinking agent to give a polymer, and then detaching the target molecule and the molecule interacting with the target molecule from the polymer thus obtained.

  本发明旨在提供一种能够重建目标分子识别场的分子识别聚合物，该目标分子识别场是通过应用分子印迹法产生的。一种可重建目标分子识别场的分子识别聚合物，该聚合物中含有与目标分子相互作用的分子，并且已构建了目标分子识别场，上述与目标分子相互作用的分子是可分离和可替换的。生产这种分子识别聚合物的方法是：合成目标分子与能与目标分子特异性和可逆性结合的分子的复合物，将这种复合物与与目标分子相互作用的分子和交联剂共聚得到聚合物，然后将目标分子和与目标分子相互作用的分子从这样得到的聚合物中分离出来。
• Methods of resolving racemic mixture to obtain (−)-huperzine A
  申请人：AMPHASTAR PHARMACEUTICALS INC.

  公开号：US10287249B2

  公开（公告）日：2019-05-14

  A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A includes: separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.

  一种将(±)-Huperzine A的外消旋混合物解析为(-)-Huperzine A的方法包括通过手性高效液相色谱法（HPLC）从(±)-Huperzine A的外消旋混合物中分离出(-)-Huperzine A，手性高效液相色谱法使用的流动相包括醇和选自二氯甲烷、三氯甲烷及其混合物的溶液，手性高效液相色谱法使用的手性固定相包括多糖衍生物。
• Methods of resolving racemic mixture to obtain (−)-Huperzine A
  申请人：AMPHASTAR NANJING PHARMACEUTICALS INC.

  公开号：US10829455B2

  公开（公告）日：2020-11-10

  A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A includes: separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.

  一种将(±)-Huperzine A的外消旋混合物解析为(-)-Huperzine A的方法包括通过手性高效液相色谱法（HPLC）从(±)-Huperzine A的外消旋混合物中分离出(-)-Huperzine A，手性高效液相色谱法使用的流动相包括醇和选自二氯甲烷、三氯甲烷及其混合物的溶液，手性高效液相色谱法使用的手性固定相包括多糖衍生物。
• MOLECULAR RECOGNITION POLYMER ENABLING RECONSTRUCTION OF RECOGNITION FIELD FOR TARGET MOLECULE AND METHOD OF PRODUCING THE SAME
  申请人：Takeuchi Toshifumi

  公开号：US20090053825A1

  公开（公告）日：2009-02-26

  A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which is produced by applying the molecular imprinting method is disclosed. A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which has a molecule interacting with the target molecule in the polymer and in which the recognition field for a target molecule has been constructed and the above-described molecule interacting with the target molecule is detachable and replaceable. This molecular recognition polymer can be produced by synthesizing a complex of the target molecule with a molecule capable of specifically and reversibly binding to the target molecule, copolymerizing this complex with a molecule interacting with the target molecule and a crosslinking agent to give a polymer, and then detaching the target molecule and the molecule interacting with the target molecule from the polymer thus obtained.
• METHODS OF RESOLVING RACEMIC MIXTURE TO OBTAIN (-)-HUPERZINE A
  申请人：AMPHASTAR PHARMACEUTICALS INC.

  公开号：US20160096808A1

  公开（公告）日：2016-04-07

  A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A includes: separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.