1-Methyl-3-N-Boc-amino-azetidine | 1017789-66-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Methyl-3-N-Boc-amino-azetidine
• 英文别名: tert-butyl N-(1-methylazetidin-3-yl)carbamate
• CAS: 1017789-66-0
• 化学式: C₉H₁₈N₂O₂
• mdl: MFCD09991727
• 分子量: 186.25
• InChiKey: JAUBBNYLYXFNEE-UHFFFAOYSA-N

物化性质

• 沸点：
  260.5±29.0 °C(Predicted)
• 密度：
  1.04±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS<br/>[FR] HÉTÉROCYCLES TRICYCLIQUES EN TANT QU'INHIBITEURS DE PROTÉINE BET
  申请人：INCYTE CORP

  公开号：WO2014143768A1

  公开（公告）日：2014-09-18

  The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

  本发明涉及三环杂环化合物，它们是BET蛋白的抑制剂，如BRD2、BRD3、BRD4和BRD-t，并且在治疗癌症等疾病方面具有用途。
• [EN] New Compounds<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：NOVARTIS TIERGESUNDHEIT AG

  公开号：WO2015071417A1

  公开（公告）日：2015-05-21

  The invention relates to compounds of the general formula (I) wherein the variable have the meanings as indicated in the claims, or a physiologically acceptable salt thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling endoparasites in warm-blooded animals.

  该发明涉及通式（I）的化合物，其中变量具有索引中所示的含义，或其生理上可接受的盐。这些活性成分具有有利的杀虫性能。它们特别适用于控制温血动物内寄生虫。
• COMPOUNDS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR
  申请人：Corvus Pharmaceuticals, Inc.

  公开号：EP3616753A1

  公开（公告）日：2020-03-04

  Disclosed herein, inter alia, are compounds of formula (I) and their use in methods for modulating Adenosine Receptors.

  本公开的内容包括式(I)的化合物及其在调节腺苷受体的方法中的应用。
• PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS
  申请人：Incyte Corporation

  公开号：US20170190689A1

  公开（公告）日：2017-07-06

  The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

  本公开提供了化合物I的化合物，或其药用盐，其调节磷脂酰肌醇3-激酶-γ（PI3Kγ）的活性，并且在治疗与PI3Kγ活性相关的疾病方面具有用途，例如自身免疫疾病、癌症、心血管疾病和神经退行性疾病。
• URACIL DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Shiro Tomoya

  公开号：US20140179670A1

  公开（公告）日：2014-06-26

  The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R 1 represents a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; R 2 represents a hydrogen atom, a halogen atom, a cyano group, —NR c R d , —N═CHN(CH 3 ) 2 , or an C 1-3 alkyl group; Ar 1 and Ar 2 independently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient.

  本发明提供：一种尿嘧啶衍生物，其由通式（I）表示，或其生理上可接受的盐（在该式中，R1代表氢原子，C1-10烷基，C2-6烯基或3-至6-成员饱和或4-至6-成员不饱和的脂肪环基，该环基可以独立地选择来自N，O和S的1到2个杂原子；R2代表氢原子，卤素原子，氰基，—NRcRd，—N═CHN(CH3)2或C1-3烷基；Ar1和Ar2独立地表示5-至6-成员芳香环基，该环基可以独立地选择来自N，O和S的1到3个杂原子；L表示6-成员芳香环基，该环基可以包含1到4个氮原子，吡唑基，三唑基或咪唑基）；以及用作与弹性酶相关的各种炎症性疾病的治疗剂或预防剂，包括该化合物或类似物作为活性成分。