N-Acetyl-3-(nitrosulfanyl)-L-valine | 168207-37-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-3-(nitrosulfanyl)-L-valine
• 英文别名: (2R)-2-acetamido-3-methyl-3-nitrosulfanylbutanoic acid
• CAS: 168207-37-2
• 化学式: C7H12N2O5S
• 分子量: 236.25
• InChiKey: GTMKBVNAJMQYKF-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease
  申请人：——

  公开号：US20020104108A1

  公开（公告）日：2002-08-01

  Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.

  公开了表达与阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤有关的蛋白质的转基因动物和转染细胞系。本发明还公开了利用这种转基因动物和转染细胞系来筛选治疗或预防阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤的潜在候选药物。本发明还涉及可用于治疗或预防阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤的新型反义寡核苷酸、核酶、三重形成 DNA 和外部引导序列。
• Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease
  申请人：——

  公开号：US20030066097A1

  公开（公告）日：2003-04-03

  Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.

  公开了表达与阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤有关的蛋白质的转基因动物和转染细胞系。本发明还公开了利用这种转基因动物和转染细胞系来筛选治疗或预防阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤的潜在候选药物。本发明还涉及可用于治疗或预防阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤的新型反义寡核苷酸、核酶、三重形成 DNA 和外部引导序列。
• Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
  申请人：——

  公开号：US20030033621A1

  公开（公告）日：2003-02-13

  Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.

  公开了表达与阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤有关的蛋白质的转基因动物和转染细胞系。本发明还公开了利用这种转基因动物和转染细胞系来筛选治疗或预防阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤的潜在候选药物。本发明还涉及可用于治疗或预防阿尔茨海默病、神经外胚层肿瘤、恶性星形细胞瘤和胶质母细胞瘤的新型反义寡核苷酸、核酶、三重形成 DNA 和外部引导序列。
• TRANSGENIC ANIMALS AND CELL LINES FOR SCREENING DRUGS EFFECTIVE FOR THE TREATMENT OR PREVENTION OF ALZHEIMER'S DISEASE
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP0975651A1

  公开（公告）日：2000-02-02
• EP0975651A4
  申请人：——

  公开号：EP0975651A4

  公开（公告）日：2005-03-09