2-hydroxy-5-phenethylaminobenzoic acid | 952498-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-5-phenethylaminobenzoic acid
• 英文别名: 2-Hydroxy-5-(2-phenylethylamino)benzoic acid
• CAS: 952498-26-9
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: TYPVQMDBCHPIFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 2-acetoxy-5-(N-phenethylamino)benzoate 在 盐酸 、 溶剂黄146 作用下， 反应 6.0h， 以88%的产率得到2-hydroxy-5-phenethylaminobenzoic acid
  参考文献：
  名称：

  A New Route of Synthesis of 5‐(N‐Phenethylamino)salicylic Acid Derivatives by Rapid and Selective Reduction of the Amide Group with NaBH₄/Acetic Acid

  摘要：

  A good yield of 5-(N-phenethylamino)salicylic acid derivatives was successfully obtained from the corresponding methyl 2-acetoxy-5-(N-phenethylamino)benzoate esters by rapid and selective reduction of the amide group in the acyl protected salicylic acid with NaBH(4)/acetic acid in dioxane followed by hydrolysis of the ester group.

  DOI：

  10.1080/00397910801982001

文献信息

• Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases
  申请人：GWAG Byoung-Joo

  公开号：US20090240079A1

  公开（公告）日：2009-09-24

  The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

  本发明涉及一种用于治疗或预防炎症性疾病和细胞损伤的药物组合物，以及一种用于治疗或预防炎症性疾病和细胞损伤的方法。本发明使用由特定化学式表示的2-羟基苯甲酸衍生物或其药用可接受的盐。本发明的化合物对治疗或预防包括胃炎、胃溃疡、胰腺炎、结肠炎、关节炎、糖尿病、动脉硬化、肾炎、肝炎、阿尔茨海默病、帕金森病和路易·盖里格病在内的细胞损伤和炎症性疾病有益。
• Compounds and compositions for treating neuronal death or neurological dysfunction
  申请人：Gwag Joo Byoung

  公开号：US20070298129A1

  公开（公告）日：2007-12-27

  The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

  本发明涉及2-羟基-烷基氨基苯甲酸衍生物及细胞坏死抑制剂和锂的组合物，以及制备该衍生物或组合物的过程，含有该衍生物或组合物的制药配方，以及通过同时或顺序给药使用该衍生物或组合物以改善神经元死亡或神经功能障碍的治疗。本发明的衍生物和组合物对于治疗神经系统疾病，如肌萎缩侧索硬化症（ALS，路易·格里格病）、脊髓性肌萎缩症、阿尔茨海默病、帕金森病、亨廷顿病、中风、创伤性脑损伤或脊髓损伤；以及治疗眼科疾病，如青光眼、糖尿病性视网膜病变或黄斑变性有用。
• COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION
  申请人：GWAG Byoung Joo

  公开号：US20120301551A1

  公开（公告）日：2012-11-29

  The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

  本发明涉及2-羟基-烷基氨基苯甲酸衍生物以及细胞坏死抑制剂和锂的组合物，制备衍生物或组合物的方法，含有衍生物或组合物的制药配方，以及通过同时或顺序给药使用衍生物或组合物来改善神经元死亡或神经功能障碍的治疗。本发明的衍生物和组合物对于治疗神经系统疾病非常有用，例如肌萎缩性侧索硬化症（ALS，路易·格里格氏病），脊髓肌肉萎缩症，阿尔茨海默病，帕金森病，亨廷顿病，中风，创伤性脑损伤或脊髓损伤；以及治疗眼科疾病，如青光眼，糖尿病性视网膜病变或黄斑变性。
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Neurotech Co., Ltd.

  公开号：EP2004164A1

  公开（公告）日：2008-12-24
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATORY DISEASES
  申请人：Neurotech Pharmaceuticals Co., Ltd.

  公开号：EP2004164B1

  公开（公告）日：2018-08-08