Sodium;4-[1-amino-2-[(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)amino]-2-oxoethyl]phenolate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Sodium;4-[1-amino-2-[(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)amino]-2-oxoethyl]phenolate
• 英文别名: sodium;4-[1-amino-2-[(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)amino]-2-oxoethyl]phenolate
• 化学式: C16H18N3NaO5S
• 分子量: 387.4
• InChiKey: BYHDFCISJXIVBV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.31
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  161
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Pharmaceutical composition containing the tromethamine salt of L-ampicillin
  申请人：Alpha-1 Biologics, LLC

  公开号：US10413530B2

  公开（公告）日：2019-09-17

  A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of β-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

  一种增加需要此类治疗的受试者血清中 CD4+ T 淋巴细胞数量的方法，包括向受试者施用药物组合物，该药物组合物包含一定量的β-内酰胺 L-异构体，能有效增加所述患者血清中 CD4+ T 淋巴细胞的数量。
• Therapeutic use of tromethamine salt of L-ampicilline in hematopoiesis, immuno-oncology therapy, and regulation of lipoprotein and apolipoprotein levels
  申请人：Alpha-1 Biologics, LLC

  公开号：US10709693B2

  公开（公告）日：2020-07-14

  A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of β-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

  一种增加需要此类治疗的受试者血清中 CD4+ T 淋巴细胞数量的方法，包括向受试者施用药物组合物，该药物组合物包含一定量的β-内酰胺 L-异构体，能有效增加所述患者血清中 CD4+ T 淋巴细胞的数量。
• Therapeutic use of levorotatory β-lactams in hematopoiesis, immuno-oncology therapy, and regulation of lipoprotein and apolipoprotein levels
  申请人：Alpha-1 Biologics, LLC

  公开号：US11324730B2

  公开（公告）日：2022-05-10

  A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of β-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

  一种增加需要此类治疗的受试者血清中 CD4+ T 淋巴细胞数量的方法，包括向受试者施用药物组合物，该药物组合物包含一定量的β-内酰胺 L-异构体，能有效增加所述患者血清中 CD4+ T 淋巴细胞的数量。
• EP3753562A1
  申请人：——

  公开号：EP3753562A1

  公开（公告）日：2020-12-23
• THERAPEUTIC USE OF LEVOROTATORY SS-LACTAMS IN HEMATOPOIESIS, IMMUNO-ONCOLOGY THERAPY, AND REGULATION OF LIPOPROTEIN AND APOLIPOPROTEIN LEVELS
  申请人：Alpha-1 Biologics, LLC

  公开号：US20180221349A1

  公开（公告）日：2018-08-09

  A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of β-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.