3-amino-N-cyclohexyl-3-phenyl-propionamide | 1016519-80-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-N-cyclohexyl-3-phenyl-propionamide
• 英文别名: 3-amino-N-cyclohexyl-3-phenylpropanamide
• CAS: 1016519-80-4
• 化学式: C₁₅H₂₂N₂O
• mdl: MFCD09928880
• 分子量: 246.352
• InChiKey: GPBBTFGODALRTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-amino-N-cyclohexyl-3-phenyl-propionamide 、 7-Chloro-6-fluoro-4-oxo-1-prop-2-ynyl-1,8-naphthyridine-3-carbonyl chloride 以 二氯甲烷 为溶剂， 反应 2.0h， 以67.5%的产率得到N-(2-N-cyclohexylcarbamoyl-1-phenylethyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-propargyl-1,8-naphthyridine-3-carboxamide
  参考文献：
  名称：

  1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

  摘要：

  A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.015
• 作为产物：
  描述：

  tert-butyl N-[3-(cyclohexylamino)-3-oxo-1-phenylpropyl]carbamate 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 以72.4%的产率得到3-amino-N-cyclohexyl-3-phenyl-propionamide
  参考文献：
  名称：

  1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

  摘要：

  A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.015

文献信息

• 1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity
  作者：Vivek Kumar、Manu Jaggi、Anu T. Singh、Alka Madaan、Vinod Sanna、Pratibha Singh、Pramod K. Sharma、Raghuveer Irchhaiya、Anand C. Burman

  DOI：10.1016/j.ejmech.2009.03.015

  日期：2009.8

  A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity. (C) 2009 Elsevier Masson SAS. All rights reserved.