4-(2,4-Dimethylphenoxy)piperidine | 946681-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2,4-Dimethylphenoxy)piperidine
• CAS: 946681-45-4
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: OBEGPAJPLHHYDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Methylene urea derivative as RAF kinasse inhibitors
  申请人：Merck Patent GmbH

  公开号：EP2426122A1

  公开（公告）日：2012-03-07

  The present invention relates to methylene urea derivatives of formula I, the use of the compounds of formula I as inhibitors of raf-kinase, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

  本发明涉及式 I 的亚甲基脲衍生物、式 I 化合物作为雷夫激酶抑制剂的用途、式 I 化合物用于制造药物组合物的用途以及治疗方法，包括将所述药物组合物施用给患者。
• Bisarylurea derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070161677A1

  公开（公告）日：2007-07-12

  The present invention relates to bisarylurea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Isoquinoline derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070191423A1

  公开（公告）日：2007-08-16

  The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Benzimidazolyl derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070191444A1

  公开（公告）日：2007-08-16

  The present invention relates to benzimidazolyl derivatives of formula (I), with the definition of R 8 , p , Ar 1 , E, D, R 9 , q and R 10 according to claim 1 , the use of the compounds of formula (I) as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Semicarbazide derivatives as kinase inhibitors
  申请人：Buchstaller Hans-Peter

  公开号：US20090253688A1

  公开（公告）日：2009-10-08

  The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.