2-[(Pyridin-3-yl)methoxy]benzonitrile | 1016808-14-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[(Pyridin-3-yl)methoxy]benzonitrile
• 英文别名: 2-(pyridin-3-ylmethoxy)benzonitrile
• CAS: 1016808-14-2
• 化学式: C₁₃H₁₀N₂O
• mdl: MFCD09950635
• 分子量: 210.23
• InChiKey: OFACKFCQRRDBCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NOVEL BENZIMIDAMIDES COMPOUNDS COMPRISING AN OXABORININ RING<br/>[FR] NOUVEAUX COMPOSÉS DE BENZIMIDAMIDES COMPRENANT UN NOYAU OXABORININE
  申请人：INST NAT SANTE RECH MED

  公开号：WO2019234075A1

  公开（公告）日：2019-12-12

  The invention relates to 4-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-3-yl)benzimidamide derivatives and their use in treating diseases and conditions of the skin (for example, Netherton syndrome, rosacea, atopic dermatitis, psoriasis and itch) caused by abnormally high levels of protease activity (particularly of serine proteases such as kallikreins). In addition, the invention relates to compositions containing the derivatives and processes for their preparation.