Acitrel | 774595-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Acitrel
• 英文别名: sodium;hydrogen carbonate;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
• CAS: 774595-73-2
• 化学式: C18H20N3NaO6S
• 分子量: 429.4
• InChiKey: UUYQXLQNUVEFGD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.21
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• A NOVEL FORMULATION, OMEPRAZOLE ANTACID COMPLEX-IMMEDIATE RELEASE FOR RAPID AND SUSTAINED SUPRESSION OF GASTRIC ACID
  申请人：SANTARUS, INC.

  公开号：EP1603537A2

  公开（公告）日：2005-12-14
• PHARMACEUTICAL FORMULATION AND METHOD FOR TREATING ACID-CAUSED GASTROINTESTINAL DISORDERS
  申请人：SANTARUS, INC.

  公开号：EP1648417A2

  公开（公告）日：2006-04-26
• A NOVEL FORMULATION, OMEPRAZOLE ANTACID COMPLEX-IMMEDIATE RELEASE FOR RAPID AND SUSTAINED SUPPRESSION OF GASTRIC ACID
  申请人：Santarus, Inc.

  公开号：EP1796641A1

  公开（公告）日：2007-06-20
• ORALE ZUBEREITUNGEN MIT OMEPRAZOL ODER PANTOPRAZOL
  申请人：Symrise AG

  公开号：EP3380085A1

  公开（公告）日：2018-10-03
• Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
  申请人：——

  公开号：US20040248942A1

  公开（公告）日：2004-12-09

  The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to a gastrointestinal disorder or disease in a subject in need thereof. In one aspect, the present invention provides a pharmaceutical composition comprising a proton pump inhibiting agent and a buffering agent for oral administration and ingestion by a subject. Upon administration, the composition contacts the gastric fluid of the stomach and increases the gastric fluid pH of the stomach to a pH that substantially prevents or inhibits acid degradation of the proton pump inhibiting agent in the gastric fluid and allows a measurable serum concentration of the proton pump inhibiting agent to be absorbed into the blood serum of the subject.