Glipizide and metformin hydrochloride | 869289-66-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Glipizide and metformin hydrochloride
• 英文别名: N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide;3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
• CAS: 869289-66-7
• 化学式: C25H39ClN10O4S
• 分子量: 611.2
• InChiKey: FMUIDSCDMUNUQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  230
• 氢给体数：
  7
• 氢受体数：
  7

文献信息

• EP1799263A4
  申请人：——

  公开号：EP1799263A4

  公开（公告）日：2009-07-29
• REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES
  申请人：The President and Fellows of Harvard College

  公开号：EP1799263A2

  公开（公告）日：2007-06-27
• [EN] REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES<br/>[FR] REDUCTION DU STRESS DU RE DANS LE TRAITEMENT DE L'OBESITE ET DU DIABETE
  申请人：HARVARD COLLEGE

  公开号：WO2006031931A2

  公开（公告）日：2006-03-23

  Endoplasmic reticulum stress has been found to be associated with obesity. Therefore, agents that reduce or prevent ER stress may be used to treat diseases associated with obesity including peripheral insulin resistance, hypergylcemia, and type 2 diabetes. Two compounds which have been shown to reduce ER stress and to reduce blood glucose levels include 4-phenyl butyric acid (PBA), tauroursodeoxycholic acid (TUDCA), and trimethylamine N-oxide (TMAO). Other compounds useful in reducing ER stress are chemical chaperones such as trimethylamine N-oxide and glycerol. The present invention provides methods of treating a subject suffering from obesity, hyperglycemia, type 2 diabetes, or insulin resistance using ER stress reducers such as PBA, TUDCA, and TMAO. Methods of screening for ER stress reducers by identifying agents that reduce levels of ER stress markers in ER stressed cells are also provided. These agents may find use in methods and pharmaceutical compositions for treating obesity-associated diseases.