(Z)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-methoxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid | 1040369-03-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-methoxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid
• CAS: 1040369-03-6
• 化学式: C₂₃H₂₅ClO₅
• 分子量: 416.901
• InChiKey: LILWNFDEGLAWNN-HMRXUNFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PPAR Modulators
  申请人：Evolva SA

  公开号：EP2363127A1

  公开（公告）日：2011-09-07

  1,3-dioxane derivatives and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.

  1,3-二恶烷衍生物及其在治疗依赖 PPAR 调节的疾病或病症（如糖尿病、癌症、炎症、神经退行性疾病和感染）中的用途。
• PRODRUGS OF SUBSTITUTED 1,3-DIOXANES AND THEIR USES
  申请人：Evolva SA

  公开号：EP2120567A1

  公开（公告）日：2009-11-25
• SUBSTITUTED 1,3-DIOXANES USEFUL AS PPAR MODULATORS
  申请人：Evolva SA

  公开号：EP2150111A1

  公开（公告）日：2010-02-10
• TREATMENT OF CARDIOVASCULAR RISK IN DIABETIC PATIENTS
  申请人：Evolva SA

  公开号：EP2934513A2

  公开（公告）日：2015-10-28
• Prodrugs of Substituted 1,3-Dioxanes and Their Uses
  申请人：Alberts Peteris

  公开号：US20130253045A1

  公开（公告）日：2013-09-26

  The present invention relates to prodrugs of compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The prodrugs of the compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.