bis[2-(N-L-phenylalanyl-L-alanyl)aminophenyl] diselenide | 1112382-99-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis[2-(N-L-phenylalanyl-L-alanyl)aminophenyl] diselenide
• 英文别名: (2S)-2-amino-N-[(2S)-1-[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoyl]amino]phenyl]diselanyl]anilino]-1-oxopropan-2-yl]-3-phenylpropanamide
• CAS: 1112382-99-6
• 化学式: C₃₆H₄₀N₆O₄Se₂
• 分子量: 778.671
• InChiKey: WHDLYPPBPLGYLV-LSGCGUROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  48
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  168
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  bis[2-(N-tert-butoxycarbonyl-L-phenylalanyl-L-alanyl)aminophenyl] diselenide 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以62%的产率得到bis[2-(N-L-phenylalanyl-L-alanyl)aminophenyl] diselenide
  参考文献：
  名称：

  Palus; Dabrowska; Pietka-Ottlik, Polish Journal of Chemistry, 2008, vol. 82, # 5, p. 1015 - 1022

  摘要：

  DOI：

文献信息

• Bis(2-aminophenyl) Diselenide Derivatives with Amino Acids Moieties as Potential Antivirals and Antimicrobials
  作者：Ewa Dąbrowska、Magdalena Pįętka-Ottlik、Jerzy Palus

  DOI：10.1080/10426500801901194

  日期：2008.4.1

  The seleno-organic compounds based on bis(2-aminophenyl) diselenide-1 are potential antiviral, antibacterial and antifungal agents.(1) In this work, we reported synthesis of bis(2-aminophenyl) diselenide derivatives 2, 3 having amino acid and dipeptide moieties. This process was realized by acylation of amine groups in 1 with N-blocked amino acids, using the active esters method (with DCC and HOBT). After removing protective groups successive N-blocked amino acids were added the same way as previously.All compounds have been tested against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (HSV-1, EMCV, VSV), in vitro. Most of them exhibited high activity against EMCV. Some of tested compounds were active against gram-positive bacteria species (Staphylococcus aureus, Staphylococcus simulans) and yeast Candida albicans.
• Palus; Dabrowska; Pietka-Ottlik, Polish Journal of Chemistry, 2008, vol. 82, # 5, p. 1015 - 1022
  作者：Palus、Dabrowska、Pietka-Ottlik、Piasecki、Mlochowski

  DOI：——

  日期：——