1-(2-(4-chlorophenyl)cyclopent-2-enyl)propan-1-one | 1028938-80-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-(4-chlorophenyl)cyclopent-2-enyl)propan-1-one
• 英文别名: 1-[2-(4-Chlorophenyl)cyclopent-2-en-1-yl]propan-1-one
• CAS: 1028938-80-8
• 化学式: C₁₄H₁₅ClO
• 分子量: 234.726
• InChiKey: LGPZCDVAGSCFRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  p-chlorophenylmethylenecyclobutane 、 丙酰氯 在 aluminum (III) chloride 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.0h， 以87%的产率得到1-(2-(4-chlorophenyl)cyclopent-2-enyl)propan-1-one
  参考文献：
  名称：

  Aluminum Chloride-Mediated Acylation of Methylenecyclobutanes. A Facile Synthetic Protocol for the Construction of Substituted Cyclopentenes

  摘要：

  Reactions of methylenecyclobutanes (MCBs) with acyl chlorides produce the corresponding substituted cyclopentene derivatives in moderate to high yields via ring enlargement in the presence of aluminum chloride under mild conditions. A plausible mechanism has been proposed on the basis of control and deuterium labeling experiments.

  DOI：

  10.1021/ol8006502

文献信息

• Aluminum Chloride-Mediated Acylation of Methylenecyclobutanes. A Facile Synthetic Protocol for the Construction of Substituted Cyclopentenes
  作者：Min Jiang、Min Shi

  DOI：10.1021/ol8006502

  日期：2008.6.5

  Reactions of methylenecyclobutanes (MCBs) with acyl chlorides produce the corresponding substituted cyclopentene derivatives in moderate to high yields via ring enlargement in the presence of aluminum chloride under mild conditions. A plausible mechanism has been proposed on the basis of control and deuterium labeling experiments.