6-(6-Acetylamino-hexanoylamino)-hexanoic acid | 97976-48-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(6-Acetylamino-hexanoylamino)-hexanoic acid
• 英文别名: 6-(6-Acetamidohexanamido)hexanoic acid；6-(6-acetamidohexanoylamino)hexanoic acid
• CAS: 97976-48-2
• 化学式: C₁₄H₂₆N₂O₄
• 分子量: 286.371
• InChiKey: YDBXZZVSBPCHAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-3-amino-3-tetradecylcarbamoylpropionic acid benzyl ester 、 6-(6-Acetylamino-hexanoylamino)-hexanoic acid 、 N,N'-二环己基碳二亚胺 在 chloroform methanol 作用下， 以 二氯甲烷 为溶剂， 以to provide 250 mg of (s)-3-[6-(6-acetamidohexanamido)hexanamido]-3-tetradecylcarbamoylpropionic acid benzyl ester的产率得到(s)-3-[6-(6-Acetamidohexanamido)hexanamido]-3-tetradecylcarbamoylpropionic acid benzyl ester
  参考文献：
  名称：

  Fatty acid derivatives and process of producing them

  摘要：

  本发明涉及一种以一般式##STR1##表示的脂肪酸衍生物及其盐。该发明的化合物具有出色的纤溶作用和高度改善的溶解度。

  公开号：

  US04629736A1

文献信息

• Fatty acid derivatives and processes of producing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0136879A2

  公开（公告）日：1985-04-10

  Water soluble fibrinolytic fatty acid derivatives of formula (I), and salts thereof in which R' represents an alkanoylamino group the carbon chain of which may be interrupted by at least one oxygen atom, an alkanoyloxy group the carbon chain of which is interrupted by at least one oxygen atom, an alkoxyimino group, or a group shown by the formula R3-(NH-Y-CO)m-Z-(wherein R3 represents an alkanoyl group or a C1-C5 alkylsulfonyl group; Y represents an alkylene group; m represents 1 or 2; and Z represents an oxygen atom or an imino group); R2 represents an alkyl group, an alkylaminocarbonyl group the carbon chain of which may be interrupted by at least one oxygen atom, or an alkoxyaminocarbonyl group the carbon chain of which is interrupted by at least one oxygen atom; represents a single bond or a double bond; a is zero when is a double bond and 1 when is a single bond; b is 0 or 1; c is 0 or 1; n represents an integer of 1 to 3; and A and B are the same or different amino acid residues. Various processes for the production of these compounds are as described.

  式(I)的水溶性纤溶脂肪酸衍生物及其盐类 其中 R'代表碳链可能被至少一个氧原子打断的烷酰氨基、碳链被至少一个氧原子打断的烷酰氧基、烷氧基亚氨基或式 R3-(NH-Y-CO)m-Z-（其中 R3 代表烷酰基或 C1-C5 烷基磺酰基；Y 代表亚烷基；m 代表 1 或 2；Z 代表氧原子或亚氨基）； R2 代表烷基、烷基氨基羰基（其碳链可被至少一个氧原子打断）或烷氧基氨基羰基（其碳链被至少一个氧原子打断）； 代表单键或双键； 当为双键时，a 为 0，当为单键时，a 为 1； b 为 0 或 1； c 为 0 或 1； n 代表 1 至 3 的整数；以及 A 和 B 是相同或不同的氨基酸残基。 生产这些化合物的各种工艺如上所述。
• Compound Having Amino Acid Residue or Peptide Residue and Process for Producing the Same
  申请人：Ikeda Hisafumi

  公开号：US20080234464A1

  公开（公告）日：2008-09-25

  An object of the present invention is to provide a compound with a structure wherein amino acid or oligopeptide side chains are bonded to a main chain. The present invention provides a compound represented by the following formula (1). wherein n1 to n3, and m1 to m6 are certain integers; Y is a hydroxyl or an amino group; E is N or CH; R is an amino acid residue, or a peptide residue consisting of 2 to 100 amino acid residues; and L is a hydrogen atom, a group containing a lipid group, a group containing a fatty acid residue, or a group containing a fluorescent group.
• FLUORESCENTLY LABELED NUCLEOSIDE TRIPHOSPHATES AND ANALOGS THEREOF FOR SEQUENCING NUCLEIC ACIDS
  申请人：Quake Stephen R.

  公开号：US20100190151A1

  公开（公告）日：2010-07-29

  The invention provides methods for sequencing a nucleic acid, and particularly methods for synthesizing fluorescently labeled nucleoside triphosphates and related analogs for sequencing nucleic acids.
• COMPOUNDS AND THERAPEUTIC USES THEREOF
  申请人：CENTAURI THERAPEUTICS LIMITED

  公开号：US20210369850A1

  公开（公告）日：2021-12-02

  The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and a disease or disorder mediated and/or caused by an infective agent, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.
• US4629736A
  申请人：——

  公开号：US4629736A

  公开（公告）日：1986-12-16