4-(piperidine-1-sulfonyl)morpholine | 71173-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(piperidine-1-sulfonyl)morpholine
• 英文别名: N-Cyclopentamethylen-4-morpholin-sulfamid；N,N-Pentamethylen-4-morpholinosulfonamid；4-Piperidin-1-ylsulfonylmorpholine
• CAS: 71173-07-4
• 化学式: C₉H₁₈N₂O₃S
• 分子量: 234.32
• InChiKey: FITXCUFMGMHHRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  哌啶 、 1-(morpholine-4-sulfonyl)-1H-benzotriazole 反应 0.17h， 以88%的产率得到4-(piperidine-1-sulfonyl)morpholine
  参考文献：
  名称：

  Synthesis of o-Sulfamidotriazobenzenes from 1,1‘-Sulfonylbis(benzotriazole)

  摘要：

  Easily accessible 1,1'-sulfonylbis(benzotriazole) (Bt(2)SO(2), 1) reacts with secondary amines at room temperature to afford (i) the corresponding o-sulfamidotriazobenzenes 2a-d (53-75%) via concurrent substitution of the first and ring opening of the second benzotriazolyl group and (ii) N-sulfonylbenzotriazoles 3b, c, e, f (7-73%). 1-(Morpholine-4-sulfonyl)-1H-benzotriazole 3c reacts with piperidine, pyrolidine, and N-methylpiperazine under microwave irradiation (120 W) at 120 degrees C for 10 min to give the unsymmetrical sulfamides 4a-c (80-90%).

  DOI：

  10.1021/jo0705723

文献信息

• Synthesis of <i>o</i>-Sulfamidotriazobenzenes from 1,1‘-Sulfonylbis(benzotriazole)
  作者：Alan R. Katritzky、Levan Khelashvili、Khanh N. B. Le、Prabhu P. Mohapatra、Peter J. Steel

  DOI：10.1021/jo0705723

  日期：2007.7.1

  Easily accessible 1,1'-sulfonylbis(benzotriazole) (Bt(2)SO(2), 1) reacts with secondary amines at room temperature to afford (i) the corresponding o-sulfamidotriazobenzenes 2a-d (53-75%) via concurrent substitution of the first and ring opening of the second benzotriazolyl group and (ii) N-sulfonylbenzotriazoles 3b, c, e, f (7-73%). 1-(Morpholine-4-sulfonyl)-1H-benzotriazole 3c reacts with piperidine, pyrolidine, and N-methylpiperazine under microwave irradiation (120 W) at 120 degrees C for 10 min to give the unsymmetrical sulfamides 4a-c (80-90%).