2-Fluoro-6-methoxy-N-methylaniline | 502435-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Fluoro-6-methoxy-N-methylaniline
• CAS: 502435-19-0
• 化学式: C₈H₁₀FNO
• 分子量: 155.17
• InChiKey: XLZOBEZHMQLSFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED DIHYDROPYRROLOPYRAZOLE DERIVATIVE
  申请人：UBE Industries, Ltd.

  公开号：EP3309163A1

  公开（公告）日：2018-04-18

  The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia), two R moieties each independently represent a C1-3 alkyl group or the like; and R1, R2 and R3 each independently represent an optionally substituted linear or branched C1-4 alkyl group.

  本发明提供了通式（Ia）所代表的化合物或其药理学上可接受的盐。在通式（Ia）中，两个 R 子各自独立地代表一个 C1-3 烷基或类似物；R1、R2 和 R3 各自独立地代表一个任选取代的直链或支链 C1-4 烷基。
• PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR
  申请人：Medshine Discovery Inc.

  公开号：EP3741756A1

  公开（公告）日：2020-11-25

  Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.

  本发明提供了一类 KRAS G12C 缄默素抑制剂，尤其涉及由式（I）代表的化合物、其异构体及其药学上可接受的盐。
• SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Janssen Pharmaceuticals Inc.

  公开号：EP2454239B1

  公开（公告）日：2014-08-13
• NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Wu Tongfei

  公开号：US20120135981A1

  公开（公告）日：2012-05-31

  The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R 1 , R 2 , A 1 , A 2 , A 3 , A 4 , X, and Het 1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
• US8946266B2
  申请人：——

  公开号：US8946266B2

  公开（公告）日：2015-02-03