N-(2-Amino-1-methyl-2-oxoethyl)-2,2-dimethylpropanamide | 132990-11-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-Amino-1-methyl-2-oxoethyl)-2,2-dimethylpropanamide
• 英文别名: N-(1-amino-1-oxopropan-2-yl)-2,2-dimethylpropanamide
• CAS: 132990-11-5
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.227
• InChiKey: LGFVWDBYXZIDFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-Amino-1-methyl-2-oxoethyl)-2,2-dimethylpropanamide 在 1-丙基磷酸酐 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， 反应 24.0h， 生成 N-(1-formamido-1-oxopropan-2-yl)pivalamide
  参考文献：
  名称：

  An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)

  摘要：

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.046

文献信息

• DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  申请人：Molteni Valentina

  公开号：US20090012094A1

  公开（公告）日：2009-01-08

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文介绍了一种包含二芳胺结构特征的化合物。还介绍了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的制药组合物和药物。本文还介绍了使用这种化合物、制药组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• ISOXAZOLINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
  申请人：FMC Corporation

  公开号：US20210309652A1

  公开（公告）日：2021-10-07

  Disclosed are Compounds of Formula 1 or 1′, wherein Q is and R 1 , R 2 , R 3 , J and X are as defined in the disclosure. Also disclosed are compositions containing the Compounds of Formula 1 or Formula 1′ and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a Compound or a composition of the invention.
• US7563894B2
  申请人：——

  公开号：US7563894B2

  公开（公告）日：2009-07-21
• US7514447B2
  申请人：——

  公开号：US7514447B2

  公开（公告）日：2009-04-07