5-Hydroxy-4-methylhexanoic acid | 98354-01-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-Hydroxy-4-methylhexanoic acid
• CAS: 98354-01-9
• 化学式: C₇H₁₄O₃
• 分子量: 146.18
• InChiKey: SBBKRBOBPXADPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• PROCESS FOR THE HYDROFORMYLATION OF AN ETHYLENICALLY UNSATURATED COMPOUND
  申请人：DRENT Eit

  公开号：US20070238892A1

  公开（公告）日：2007-10-11

  Process for the hydroformylation of an optionally substituted ethylenically unsaturated compound by reaction thereof with carbon monoxide and hydrogen in the presence of a specific catalyst system. The specific catalyst system comprises: (a) a source of group VIII metal cations; (b) a diphosphine ligand having the general formula I X 1 —R—X 2 (I) wherein X 1 and X 2 each independently represent an optionally substituted cyclic group with at least 5 ring atoms, of which one is a phosphorus atom, and R represents a bivalent optionally substituted bridging group, connected to each phosphorus atom by a sp2 hybridized carbon atom; (c) an acid having a pKa<3, measured in an aqueous solution at 18° C. or a salt derived thereof; and (d) a source of halide anions. Furthermore some specific bidentate diphosphines used in this process are described.

  一种通过在特定催化剂系统存在下，将一种可选择取代乙烯基不饱和化合物与一氧化碳和氢气反应的水合甲酰化过程。该特定催化剂系统包括：(a)一种八号族金属阳离子源；(b)一种具有通式IX1-R-X2(I)的二膦配体，其中X1和X2分别独立地表示至少有5个环原子的可选择取代的环状基团，其中一个为磷原子，而R代表一个双价可选择取代的桥接基团，由一个sp2杂化碳原子连接到每个磷原子；(c)酸，其在18℃的水溶液中测得的pKa<3，或其衍生盐；以及(d)卤素阴离子源。此外，还描述了在该过程中使用的一些特定的双膦配体。
• Novel Use of Nonenolide
  申请人：Kindel Gunter

  公开号：US20070297993A1

  公开（公告）日：2007-12-27

  The present invention relates to the use of nonenolide for imparting, modifying and/or intensifying one or more smell or flavour impressions from the group consisting of hay, coumarin, lactone and richness in the mouth.

  本发明涉及使用非烯酮来赋予、改变和/或增强一种或多种气味或口味印象，所述气味或口味印象来自于草、香豆素、内酯和口感丰富度的组合。
• Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols
  申请人：Eastman Chemical Company

  公开号：US10266467B2

  公开（公告）日：2019-04-23

  A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H2. The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.

  利用醇类作为还原剂而不是传统的 H2 气体，通过氢化 1,2-二氧 化有机化合物形成沧烷二醇的转移氢化工艺。与使用 H2 进行酯加氢的典型方法相比，转移加氢是在较温和的温度和压力条件下进行的。较温和的操作条件带来了诸多好处，例如降低了工业规模生产的操作和资本成本，以及由于避免了反应混合物和产品暴露于高温而产生的副产品，从而节省了产品提纯费用。