N'-[(E)-(3-methoxyphenyl)methylidene]furan-2-carbohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N'-[(E)-(3-methoxyphenyl)methylidene]furan-2-carbohydrazide
• 英文别名: N-[(E)-(3-methoxyphenyl)methylideneamino]furan-2-carboxamide
• 化学式: C₁₃H₁₂N₂O₃
• 分子量: 244.25
• InChiKey: HIQXRWDKWCKIPY-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Apo ai expression accelerating agent
  申请人：——

  公开号：US20040248950A1

  公开（公告）日：2004-12-09

  Pharmaceutical compositions for enhancing the expression of apoAI are provided. Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): 1 in which Y 1 is O, S or NR 1 ; Y 2 , Y 3 , Y 4 and Y 5 are CR 2 or N; CR 3 or N; CR 4 or N; and CR 5 or N, respectively; R 1 is A 1 , -Z-A 2 , a hydrogen, a lower alkyl and the like; R 2 , R 3 , R 4 and R 5 are A 1 , -Z-A 2 , a hydrogen, a halogen, and like; -Z- is a single bond, —CR 6 ═CR 7 —, and the like; R 6 and R 7 are a hydrogen or a lower alkyl; and A 1 and A 2 are an aryl, a heterocyclic ring, and the like; are disclosed.

  提供了增强apoAI表达的制药组合物。所述制药组合物用于增强apoAI表达，包括式（I）的化合物：1其中Y1为O、S或NR1；Y2、Y3、Y4和Y5分别为CR2或N；CR3或N；CR4或N；CR5或N；R1为A1、-Z-A2、氢、低碳基等；R2、R3、R4和R5分别为A1、-Z-A2、氢、卤素等；-Z-为单键，-CR6═CR7-等；R6和R7为氢或低碳基；A1和A2为芳基、杂环环等。