1,3-dioctyl-1,3-dihydro-2H-benzo[d]imidazol-2-one | 161823-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1,3-dioctyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
• 英文别名: 1,3-Dioctyl-1,3-dihydro-2H-benzimidazol-2-one；1,3-dioctylbenzimidazol-2-one
• CAS: 161823-50-3
• 化学式: C₂₃H₃₈N₂O
• 分子量: 358.568
• InChiKey: YPZSSMRUWCABBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-羟基苯并咪唑 、 1-碘辛烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以3 %的产率得到1,3-dioctyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
  参考文献：
  名称：

  [EN] MODULATORS OF SK4 POTASSIUM CHANNEL AND USES THEREOF
  [FR] MODULATEURS DU CANAL POTASSIQUE SK4 ET LEURS UTILISATIONS

  摘要：

  Compounds capable of interacting with the calmodulin-PIP2 binding domain of the SK4 channel to thereby interfere with the Ca2+-dependent activation of the SK4 channel and uses thereof in downregulating an activity of an SK4 channel in a subject in need thereof, are disclosed. Also disclosed is a method of identifying a candidate compound that is capable of downregulating an activity of SK4 channel, based on its interaction with the calmodulin-PIP2 binding domain of the SK4 channel.

  公开号：

  WO2023135603A1

文献信息

• Immunoassay method
  申请人：Ohzeki Katsuhisa

  公开号：US20080145869A1

  公开（公告）日：2008-06-19

  The present invention provides a method for immunoassaying an object to be analyzed including: causing to act, on a specimen or a sample including the specimen, a first protein (Y), which can specifically recognize the object to be analyzed in the specimen and is modified by a labeling substance, so as to form a complex including the object to be analyzed and Y; and measuring the labeling substance contained in the complex or the labeling substance contained in the free protein (Y), wherein the measurement of the labeling substance is performed by a chemiluminescent method which includes sensing the light generated by chemiluminescence using a photothermographic material including at least an organic silver salt, a reducing agent for silver ions and a photosensitive silver halide to form a latent image, and making the latent image visible by thermal development. An easy, quick, and highly precise immunoassay method is provided.

  本发明提供了一种免疫分析待分析物的方法，包括：在含有待分析物的样本或标本上作用第一蛋白（Y），该蛋白可以特异性地识别标本中的待分析物并被标记物质改性，以形成包括待分析物和Y的复合物；并测量复合物中包含的标记物质或自由蛋白（Y）中包含的标记物质。其中，标记物质的测量是通过化学发光法进行的，该法包括使用至少含有有机银盐、银离子还原剂和感光银卤化物的光热材料来感应化学发光所产生的光，并通过热发展使潜像可见。提供了一种简单、快速、高精度的免疫分析方法。
• US7214476B2
  申请人：——

  公开号：US7214476B2

  公开（公告）日：2007-05-08
• US7448533B2
  申请人：——

  公开号：US7448533B2

  公开（公告）日：2008-11-11
• US7497107B2
  申请人：——

  公开号：US7497107B2

  公开（公告）日：2009-03-03
• [EN] MODULATORS OF SK4 POTASSIUM CHANNEL AND USES THEREOF<br/>[FR] MODULATEURS DU CANAL POTASSIQUE SK4 ET LEURS UTILISATIONS
  申请人：[en]RAMOT AT TEL-AVIV UNIVERSITY LTD.

  公开号：WO2023135603A1

  公开（公告）日：2023-07-20

  Compounds capable of interacting with the calmodulin-PIP2 binding domain of the SK4 channel to thereby interfere with the Ca2+-dependent activation of the SK4 channel and uses thereof in downregulating an activity of an SK4 channel in a subject in need thereof, are disclosed. Also disclosed is a method of identifying a candidate compound that is capable of downregulating an activity of SK4 channel, based on its interaction with the calmodulin-PIP2 binding domain of the SK4 channel.