2-[(3-bromophenyl)methylsulfanyl]-N-[(E)-(3-methoxy-4-prop-2-enoxyphenyl)methylideneamino]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[(3-bromophenyl)methylsulfanyl]-N-[(E)-(3-methoxy-4-prop-2-enoxyphenyl)methylideneamino]acetamide
• 化学式: C₂₀H₂₁BrN₂O₃S
• 分子量: 449.4
• InChiKey: XRHRFILKIOEOOC-WSDLNYQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Hydrazone derivatives and uses thereof
  申请人：Bryant W. Robert

  公开号：US20070207093A1

  公开（公告）日：2007-09-06

  The present invention is directed to the use of a compound having the formula wherein R 1 , R 2 , R 3 , R 4 , L 1 , and L 2 are defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound according to the above formula.

  本发明涉及使用具有以下式子的化合物，其中R1，R2，R3，R4，L1和L2在此定义。本发明的化合物可用作某些味觉感知和功能的抑制剂。本发明还涉及包含上述式子的化合物的组合物。
• USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE
  申请人：Redpoint Bio Corporation

  公开号：EP2107908A2

  公开（公告）日：2009-10-14
• High throughput screening assay for the TRPM5 ion channel
  申请人：Bryant W. Robert

  公开号：US20070111264A1

  公开（公告）日：2007-05-17

  There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.
• Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release
  申请人：Lee S. Paul

  公开号：US20080306030A1

  公开（公告）日：2008-12-11

  The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
• High Throughput Screening Assay for the TRPM5 Ion Channel
  申请人：BRYANT Robert W.

  公开号：US20100248988A1

  公开（公告）日：2010-09-30

  There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.