N-[N-(3,4dichlorophenyl)-D,L-alanyl]-L-aspartic β-(tert-butyl ester)α-methyl ester | 208330-82-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N-(3,4dichlorophenyl)-D,L-alanyl]-L-aspartic β-(tert-butyl ester)α-methyl ester
• 英文别名: 4-O-tert-butyl 1-O-methyl (2S)-2-[2-(3,4-dichloroanilino)propanoylamino]butanedioate
• CAS: 208330-82-9
• 化学式: C₁₈H₂₄Cl₂N₂O₅
• 分子量: 419.305
• InChiKey: VOLQJOVUXGMDBX-SBNLOKMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (S)-2-(3,4-dichloro-phenylamino)-propionic acid 、 L-天冬氨酸-Α-甲酯-Β-叔丁酯盐酸盐 在 盐酸 作用下， 生成 N-[N-(3,4dichlorophenyl)-D,L-alanyl]-L-aspartic β-(tert-butyl ester)α-methyl ester
  参考文献：
  名称：

  US6096782

  摘要：

  公开号：

文献信息

• N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
  申请人：——

  公开号：US20010020097A1

  公开（公告）日：2001-09-06

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有用途。还公开了包括抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP0942923A2

  公开（公告）日：1999-09-22
• US6096782A
  申请人：——

  公开号：US6096782A

  公开（公告）日：2000-08-01
• US6495693B2
  申请人：——

  公开号：US6495693B2

  公开（公告）日：2002-12-17
• [EN] N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING beta -AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS<br/>[FR] DERIVES DE N-(ARYL/HETEROARYL) AMINOACIDE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET PROCEDES PERMETTANT D'INHIBER LA LIBERATION DE PEPTIDE beta AMYLOIDE ET/OU SA SYNTHESE A L'AIDE DE CES COMPOSES
  申请人：——

  公开号：WO1998022493A2

  公开（公告）日：1998-05-28

  [EN] Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
  [FR] L'invention a trait à des composés inhibant la libération de peptide beta -amyloïde et ou sa synthèse et, de ce fait, se révélant utiles s'agissant de traiter la maladie d'Alzheimer. Elle a également trait à des compositions pharmaceutiques contenant un composé inhibant la libération de peptide beta -amyloïde et ou sa synthèse ainsi qu'à des méthodes de traitement de la maladie d'Alzheimer, tant au plan prophylactique que thérapeutique, ces méthodes faisant intervenir lesdites compositions pharmaceutiques.