tetrahydro-2H-pyran-2-carboxamide | 89531-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: tetrahydro-2H-pyran-2-carboxamide
• 英文别名: (+/-)-Tetrahydropyran-carbonsaeure-(2)-amid；Tetrahydro-pyrano-carbonsaeure-(2)-amid；tetrahydro-pyran-2-carboxylic acid amide；Oxane-2-carboxamide
• CAS: 89531-39-5
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: MVZDZQRFEUOLOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Macrocyclic MCL-1 inhibitors and methods of use
  申请人：AbbVie Inc.

  公开号：US20190055264A1

  公开（公告）日：2019-02-21

  The present disclosure provides for compounds of Formula (I) wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

  本公开提供了Formula (I)的化合物，其中A2、A3、A4、A6、A7、A8、A15、RA、R5、R9、R10A、R10B、R11、R12、R13、R14、R16、W、X和Y具有规范中定义的任何值，以及其药学上可接受的盐，可用作治疗疾病和病况的药物，包括癌症。还提供了包含Formula (I)化合物的药物组合物。
• Organic Compounds
  申请人：Maibaum Juergen Klaus

  公开号：US20090076062A1

  公开（公告）日：2009-03-19

  Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

  揭示了具有抑制肾素作用的δ-氨基-γ-羟基-ω-芳基-烷酸酰胺化合物的化学式(I)及其盐。还揭示了包括这些化合物的药物组合物以及用于治疗高血压、动脉粥样硬化、不稳定性冠状动脉综合征、充血性心力衰竭、心肌肥大、心脏纤维化、心肌梗死后心肌病、不稳定性冠状动脉综合征、舒张功能障碍、慢性肾病、肝纤维化、糖尿病并发症（如肾病、血管病和神经病变）、冠状血管疾病、血管成形术后再狭窄、眼内压升高、青光眼、异常血管生长、高醛固酮症、认知障碍、阿尔茨海默病、痴呆症、焦虑状态和认知障碍的治疗方法。
• [EN] HETEROARYL SUBSTITUTED INDOLE COMPOUNDS USEFUL AS MMP-13 INHIBITORS<br/>[FR] COMPOSÉS INDOLE À SUBSTITUTION HÉTÉROARYLE UTILISÉS COMME INHIBITEURS DE MMP-13
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010045188A1

  公开（公告）日：2010-04-22

  Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.

  披露了公式I的化合物和组合物，如本文所述，它们是MMP-13的抑制剂。还披露了使用和制造公式I化合物的方法。
• [EN] SUBSTITUTED ARYLALKANOIC ACID DERIVATIVE AND USE THEREOF<br/>[FR] DERIVE D'ACIDE ARYLALCANOIQUE SUBSTITUE ET SON UTILISATION
  申请人：ASAHI KASEI PHARMA CORP

  公开号：WO2005016862A1

  公开（公告）日：2005-02-24

  A compound represented by the formula (I)[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting carbon atom, one of the ring-constituting carbon atoms may be replaced with V, V represents nitrogen atom, or carbon atom substituted with Zx, Zx represents a saturated alkyl group having 1 to 4 carbon atoms and the like, Rs represents -D-Rx etc., D represents a single bond, oxygen atom and the like, Rx represents a saturated alkyl group having 3 to 8 carbon atoms and the like, AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or a heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms and the like] or a salt thereof. A compound having prostaglandin production-suppressing action and leukotriene production-suppressing action is provided.

  化合物的化学式为（I）。在该式中，Link代表一个由1至3个碳原子组成的饱和或不饱和直链烃链，芳环（E）中的C2至C6独立代表构成环的碳原子，构成环的碳原子中的一个可以被V取代，V代表氮原子，或者被Zx取代的碳原子，Zx代表由1至4个碳原子组成的饱和烷基基团等，Rs代表-D-Rx等，D代表单键、氧原子等，Rx代表由3至8个碳原子组成的饱和烷基基团等，AR代表部分不饱和或完全不饱和的紧凑双环碳环或杂环，Y代表氢原子、由1至4个碳原子组成的低烷基基团等，或其盐。提供了一种具有抑制前列腺素产生和抑制白三烯产生作用的化合物。
• [EN] DEUTERATED ANALOGS OF ETIFOXINE, THEIR DERIVATIVES AND USES THEROF<br/>[FR] ANALOGUES DEUTÉRÉS D'ÉTIFOXINE, LEURS DÉRIVÉS ET LEURS UTILISATIONS
  申请人：ANVYL LLC

  公开号：WO2016154039A1

  公开（公告）日：2016-09-29

  This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

  这项发明涉及到公式1的依托氟辛的氘代物、溶剂化合物、前药以及其药用盐，以及它们的制备和使用方法，以及药物组合物。简而言之，这项发明通常涉及到依托氟辛的氘代物，以及它们的制备和使用方法，以及含有它们的药物组合物。