2-Isobutyrylamino-2-hydroxymethyl-propanol-(1) | 99903-94-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Isobutyrylamino-2-hydroxymethyl-propanol-(1)
• 英文别名: 2-isobutyrylamino-2-methyl-propane-1,3-diol；N-(1,3-dihydroxy-2-methylpropan-2-yl)-2-methylpropanamide
• CAS: 99903-94-3
• 化学式: C₈H₁₇NO₃
• 分子量: 175.228
• InChiKey: WXYRQYNPONMRTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Isobutyrylamino-2-hydroxymethyl-propanol-(1) 以 xylene 为溶剂， 生成 (2-isopropyl-4-methyl-4,5-dihydro-oxazol-4-yl)-methanol
  参考文献：
  名称：

  Rosnati,V.; Misiti,D., Gazzetta Chimica Italiana, 1960, vol. 90, p. 573 - 583

  摘要：

  DOI：
• 作为产物：
  描述：

  (2-isopropyl-4-methyl-4,5-dihydro-oxazol-4-yl)-methanol 在 sodium hydroxide 作用下， 生成 2-Isobutyrylamino-2-hydroxymethyl-propanol-(1)
  参考文献：
  名称：

  Rosnati,V.; Misiti,D., Gazzetta Chimica Italiana, 1960, vol. 90, p. 573 - 583

  摘要：

  DOI：

文献信息

• POLYMER PARTICLES
  申请人：Hawkett Brian Stanley

  公开号：US20120128743A1

  公开（公告）日：2012-05-24

  The present invention relates to a method of forming polymer on the surface of polymer particles, the method comprising: (i) providing a dispersion comprising a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and a RAFT agent as a stabiliser for said organic phase; (ii) polymerising the one or more ethylenically unsaturated monomers under the control of the RAFT agent to form an aqueous dispersion of seed polymer particles; (iii) crosslinking the seed polymer particles; (iv) swelling the crosslinked seed particles with one or more ethylenically unsaturated monomers to form an aqueous dispersion of monomer swollen crosslinked seed polymer particles; (v) increasing the temperature of the monomer swollen crosslinked seed polymer particles to expel at least some of the monomer therein onto the surface of the particles; and polymerising at least the expelled monomer to form polymer on the surface of the particles.

  本发明涉及一种在聚合物颗粒表面形成聚合物的方法，该方法包括：(i)提供一个分散体系，该分散体系包括连续的水相、分散的有机相，该有机相包括一种或多种乙烯基不饱和单体以及RAFT剂作为有机相的稳定剂；(ii)在RAFT剂的控制下聚合一种或多种乙烯基不饱和单体，形成种子聚合物颗粒的水性分散体系；(iii)交联种子聚合物颗粒；(iv)用一种或多种乙烯基不饱和单体膨胀交联的种子颗粒，形成乙烯基不饱和单体膨胀交联种子聚合物颗粒的水性分散体系；(v)提高乙烯基不饱和单体膨胀交联种子聚合物颗粒的温度，使其中至少一部分乙烯基不饱和单体排出到颗粒表面；并聚合至少被排出的乙烯基不饱和单体，在颗粒表面形成聚合物。
• Aqueous dispersions of polymer particles
  申请人：Such Henry Christopher

  公开号：US20060223936A1

  公开（公告）日：2006-10-05

  The invention provides a method for preparing an aqueous dispersion of polymer particles comprising the following steps: (i) preparing a dispersion having a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and an amphiphilic RAFT agent as a stabiliser for said organic phase, and (ii) polymerising said one or more ethylenically unsaturated monomers under the control of said amphiphilic RAFT agent to form said aqueous dispersion of polymer particles, novel amphiphilic RAFT agents for use in this method, novel RAFT agents useful in making these amphiphilic RAFT agents and methods for their manufacture.

  本发明提供了一种制备聚合物颗粒水分散液的方法，包括以下步骤：(i)制备一个连续的水相分散体系，其中包括一个或多个乙烯基不饱和单体的分散有机相，并且含有一种两亲性RAFT剂作为有机相的稳定剂，以及(ii)在该两亲性RAFT剂的控制下聚合该一种或多种乙烯基不饱和单体，以形成所述聚合物颗粒的水分散液，以及在该方法中使用的新型两亲性RAFT剂，用于制备这些两亲性RAFT剂的新型RAFT剂和它们的制备方法。
• SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150148327A1

  公开（公告）日：2015-05-28

  The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R cy , C y , and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

  本发明提供了以下公式（I）的某些取代吡啶或其药学上可接受的盐，其中R1，R2，R3，R4，Rcy，Cy和t如本文所定义。 本发明还提供了包含这种化合物的制药组合物，并且提供了使用这些化合物治疗由脾酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
• Thermoplastic elastomer composition
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0409580A2

  公开（公告）日：1991-01-23

  A thermoplastic elastomer composition comprising: 99-1 parts by weight of (i) a hydrogenated diene polymer which is a hydrogenation product of a straight or branched chain block copolymer consisting of (C) a polybutadiene block segment having a 1,2-vinyl content of not more than 20% and (D) a block segment which is a polybutadiene or an alkenyl aromatic compound-butadiene copolymer, the butadiene portion of which has a 1,2-vinyl content of 25-95%, the block structure of said straight or branched chain block copolymer being represented by the formula, C-(D-C)n or (C-D)m in which C means the above-mentioned polybutadiene block segment (C), D means the above-mentioned block segment (D), n means an integer of 1 or more and m means an integer of 2 or more, at least 90% of the double bond in the butadiene portion of the straight or branched chain block copolymer having been hydrogenated, or (i′) a modified hydrogenated diene polymer in which 0.01 to 10 mole % of at least one functional group selected from the group consisting of carboxyl group, acid anhydride group, hydroxyl group, epoxy group, halogen atom and amino group is added to the hydrogenated diene polymer (i), and 1-99 parts by eight of at least one member selected from the group consisting of a thermoplastic resin and a rubbery polymer. The above thermopalstic elastomer composition has properties comparable to a vulcanized rubber and is useful in various industrial parts.

  一种热塑性弹性体组合物，包括99-1 重量份的(i)氢化二烯聚合物，它是直链或支链嵌段共聚物的氢化产物，直链或支链嵌段共聚物由(C)聚丁二烯嵌段和(D)嵌段组成，(C)聚丁二烯嵌段的 1，2-乙烯基含量不超过 20%，(D)嵌段是聚丁二烯或烯基芳香族化合物-丁二烯共聚物，其中丁二烯部分的 1，2-乙烯基含量为 25-95%、所述直链或支链嵌段共聚物的嵌段结构由式 C-(D-C)n 或 (C-D)m 表示，其中 C 指上述聚丁二烯嵌段（C），D 指上述嵌段（D）、n 指 1 或更多的整数，m 指 2 或更多的整数，直链或支链嵌段聚合物丁二烯部分中至少 90% 的双键已氢化，或 (i′) 改性氢化二烯聚合物，其中 0.01至10摩尔％的至少一种选自羧基、酸酐基、羟基、环氧基、卤素原子和氨基的官能团，以及1-99份之八的至少一种选自热塑性树脂和橡胶聚合物的成员。上述热塑性弹性体组合物的性能与硫化橡胶相当，可用于各种工业部件。
• Dispersant anti-oxidant viscosity index improver and lubricating oil composition containing same
  申请人：TEXACO DEVELOPMENT CORPORATION

  公开号：EP0413429A1

  公开（公告）日：1991-02-20

  A multi-functional lubricant additive havingt dispers­ant, anti-oxidant and VI-improving properties can be prepared by reacting a polymer comprising from 15 to 80 mole percent of ethylene, from 20 to 85 mole percent of at least one C₃ -C₁₀ alpha-monoolefin, and from 0 to 15 mole percent of a non-conjugated diene or triene, and having an average molecular weight from 5,000 to 500,000, with a nitrosodi­phenylamine compound having the formula: in which R and R′ which may be the same or different, each represents hydrogen or an alkyl , alkenyl or alkoxyl radical having from 1 to 10 carbon atoms, and which may contain oxygen, nitrogen or sulfur.

  一种具有分散剂、抗氧化剂和 VI 改进特性的多功能润滑油添加剂可通过以下方法制备：将含有 15 至 80 摩尔%的乙烯、20 至 85 摩尔%的至少一种 C₃-C₁₀α-单烯烃和 0 至 15 摩尔%的非共轭二烯或三烯且平均分子量为 5,000 至 500,000 的聚合物与具有以下式子的亚硝基二苯胺化合物反应： 其中 R 和 R′可以相同或不同，各自代表氢或具有 1 至 10 个碳原子的烷基、烯基或烷氧基，并可包含氧、氮或硫。